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Erythrocyte production and survival in Rauscher murine leukemia virus-infected BABL/c mice


Erythrocyte production and survival in Rauscher murine leukemia virus-infected BABL/c mice



Cancer Research 40(11): 4270-4275



ISSN/ISBN: 0008-5472

PMID: 7471066

Red blood cell production in normal and Rauscher murine leukemia virus-infected mice was investigated using 55Fe as a marker. Autoradiography showed increased centage labeling of red blood cells in blood smears, taken at different time intervals after pulse labeling of the erythroid precursor cells. The total reticulocyte production per unit time > 2.8-fold in Rauscher murine leukemia virus-infected mice as compared with that in uninfected mice. The life span as indicated by time that 1/2 of labeled erythrocytes disappeared (t1/2) was reduced to 1/4 of that of erythrocytes of uninfected mice. The functioning of the newly formed cells was analyzed by measuring the glucose utilization vs. lactate production and by measuring the activities of enzymes involved in glucose metabolism. Comparison of glucose metabolism in normal and leukemic mice, and in mice recovering from artificially induced anemia, revealed that the metabolic activity of erythrocytes from leukemic mice corresponds to the activity of young erythrocyte populations. The increased reticulocyte production is, apparently, a result of the degree of anemia in infected animals. This anemia is not compensated for, since the loss of erythrocytes surpasses the flux of new red blood cells from the hematopoietic organs into the peripheral blood.

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Accession: 005381890

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