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Establishment and characterization of human bone marrow derived lymphocytic lymphoma cell lines balm 3 balm 4 and balm 5 intra clonal variation in the bone marrow derived cell differentiation stage



Establishment and characterization of human bone marrow derived lymphocytic lymphoma cell lines balm 3 balm 4 and balm 5 intra clonal variation in the bone marrow derived cell differentiation stage



International Journal of Cancer 24(5): 572-578



This study describes the establishment of 3 non-Burkitt B[bone marrow-derived] lymphoma cell lines (BALM-3, BALM-4 and BALM-5) originating from the pleural effusion of a patient with a poorly differentiated diffuse lymphocytic lymphoma. The cells of BALM-3, -4 and -5 exhibited a number of properties which distinguish them from the usual B-cell type lymphoblastoid cell lines. They lacked the Epstein-Barr virus genome and had abnormal chromosome constitutions including a 14q+ marker. The presence of the identical surface immunoglobulin isotypes (.gamma. and .vkappa. chain determinants), and la-like B-cell-associated antigen in the cultured cells and in the fresh lymphoma cells in vivo was demonstrated. Apparently these cell lines have B-cell characteristics and were derived from the original tumor cell population. BALM-5 cells showed somewhat different growth, cell surface marker profile and functional characteristics compared to those of BALM-3, and -4 cells. The BALM-5 cells were probably at different stages of B-cell maturation than those of BALM-3 and -4, even though all 3 cell lines (established in 3 separate flasks) originated from the cells of the same pleural effusion of a lymphoma with monoclonal B-cell characteristics.

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Accession: 005384556

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