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Estrogen induced destabilization of yolk precursor protein messenger rna in avian liver


, : Estrogen induced destabilization of yolk precursor protein messenger rna in avian liver. Journal of Biological Chemistry 263(6): 2625-2631

In addition to regulating gene expression at the level of transcription, estrogen is generally considered to selectively stabilize induced mRNAs against degradation. As a result of mRNA stabilization, estrogen-induced mRNAs accumulate to much higher levels in target cells, and the encoded proteins are made at much greater rates than would occur on the basis of transcriptional activation alone. The present study examined the effect of estrogen on the stabilities of avian liver mRNAs that code for the yolk precursor proteins apolipoprotein (apo) II and vitellogenin (VTG) II. The results show that the degradation rates of apoII and VTGII mRNAs during hormone withdrawal are dramatically altered by the duration of prior estrogen treatment. During the 2 days required for the hormonal inductions of these mRNAs to new steady states, the turnover rates of both mRNAs were the same in the presence and absence of estrogen (t1/2 = 13 h). This result indicates that mRNA stabilization does not contribute to the extensive accumulation of apoII and VTG II mRNAs. When the duration of estrogen treatment was extended beyond 3 days, however, hormone withdrawal led to the rapid (t1/2 = 1.5 h) and selective destabilization of these mRNAs. This result suggests that estrogen induced a destabilization activity that was only functional followihg hormone withdrawal. Thus, the point at which estrogen alters mRNA stabiliity is at the level of mRNA degradation. An absence of detectable apoII mRNA degradation intermediates during either the slow or rapid mode of mRNA decay suggests that the rate-limiting step for apoII mRNA turnover is an estrogen-sensitive targeting event that marks the mRNA for rapid degradation.

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Du-Bois, M. J. G. J.; Bierhorst-Eijlander, A.; Meinesz, A.; Schellekens, P. T. A., 1978: Cellular requirements for lymphocyte re stimulation after a 1st challenge in vitro. Human peripheral blood lymphocytes from donors who were sensitized in vivo to bacterial antigens were stimulated by these antigens in vitro. When the cells from these 1st cultures were challenged with irradiated allogeneic lymphocytes, a prolifera...

Pazvakavambwa, I.E., 1999: Partial atrioventriculae septal defect causing confusion with rheumatic heart disease in children in Harare: Case reports. Four cases of partial atrioventricular septal defect (ATSD) which had been confused with rheumatic heart disease are presented. The need for a full clinical and echocardiographic assessment to reduce this confusion and avoid potentially harmful th...

Sidorov, K. P., 1957: The control of pests of vegetable cultures. A mixture of DDT and hexachlorocyclohexane (HCCH) in equal amounts had a prolonged and high effect against a complex of gnawing and sucking pests of vegetable cultures. Dusting of cabbage with HCCH against aphids produces great economic results. E...

Ardre F., 1969: Observations on pelvetia canaliculata. Margalef, Ramon (Edited By) Proceedings Of The Sixth International Seaweed Symposium Actas Del Sexto Simposio Internacional Sobre Algas Marinas Xxiii + 782p Illus Maps Subsecretaria De La Marina Mercante, Direccion General De Pesca Maritima: Madrid, Spain 31-40

Reed, Floyd, A., 2000: Two-locus epistasis with sexually antagonistic selection A genetic Parrondos paradox. An example is provided where, with antagonistic selection and epistatic interaction of alleles at two loci, an autosomal allele can rise in frequency, persist in the population, and even continue to fixation, despite having an apparently lower av...

Lessley B.A.; Aalseth E.P.Jr; Hawman C.H., 1989: Suppression of bovine in vitro fertilization by pretreatment of spermatozoa with 1 10 phenanthroline a membrane permeant metalloprotease inhibitor. Biology of Reproduction 40(SUPPL 1): 62

Becker, Andrea; Albrecht, Catrin; Knaapen, Ad, M.; Schins, Roel, P. F.; Hoehr, Doris; Ledermann, Kirstin; Borm, Paul, J. A., 2006: Induction of CYP1A1 in rat lung cells following in vivo and in vitro exposure to quartz. Respirable quartz has been classified as a human lung carcinogen, but the mechanism by which quartz exposure leads to lung cancer has not been clarified. Consistently higher risks of lung cancer are reported in smokers with quartz exposure and we...

Eddins, A. H., 1939: Some characteristics of bacterial ring rot of potatoes. The similarities and differences in the char-acteristics of bacterial ring rot and southern bacterial wilt or brown rot are discussed. When tubers affected with bacterial ring rot were held at different temps., they decayed rapidly at 70[degree]-9...

Bondarenko, S.; Kondratyeva, L., 1985: On the cestode fauna of the genus Aploparaksis Clerc, 1903 (Hymenolepididae) of birds of the family Anatidae. Acta Parasitologica Lithuanica, 21: 77-86

Taniyama T.; Arikado H., 1969: Studies on the mechanism of injurious effects of toxic gases on crop plants part 3 on the degree of injuries and a kind of typical symptom of injuries caused by sulfurous acid solution spray to rice m plants. Proceedings of the Crop Science Society of Japan 38(2): 222-228