+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a cystic fibrosis screening system incorporating a miniature sweat stimulator and disposable chloride sensor

, : Evaluation of a cystic fibrosis screening system incorporating a miniature sweat stimulator and disposable chloride sensor. Clinical Chemistry 32(5): 850-853

A new sweat test (CF Indicator; Medtronic, Inc.) for cystic fibrosis (CF) features a compact, portable configuration of electrodes that dispense pilocarpine for iontophoresis. A disposable chloride sensor patch absorbs a specified volume of sweat, in which the chloride concentration is immediately determined as less than 40, 40-60, or greater than 60 mmol/L. We assessed the performance of the system in a five-center study, in relation to the clinical diagnosis and to the Gibson-Cooke sweat test (GCST) as a control test. With sweat chloride concentrations of less than or equal to 40 mmol/L defined as normal and greater than 40 mmol/L as indicating persons at risk for CF, the new system showed 91% specificity and 100% sensitivity for CF, as compared with 92.8% and 100%, respectively, for the GCST. When we used sweat chloride concentrations of less than or equal to 60 mmol/L as probably normal and greater than 60 mmol/L as probably indicative of CF, the new system showed a 99.1% specificity and 98.6% sensitivity, vs 97.8% specificity and 97.9% sensitivity for the GCST test. In both procedures, occasionally insufficient sweat was collected, and this appeared related to the age of the subject. We conclude that the new sweat test system is potentially useful in physicians' offices, in clinics, and similar settings.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005395046

PMID: 3698274

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Lederer, J.; Vogt Rohlf, O.; Mennerich, A., 1975: Genetic progress in the Black Pied population of Lower Saxony and its effect on results of breeding value estimation. It is pointed out that objective ranking of bulls available for breeding is only possible if the dynamic development of the population is taken into account. This study estimates the progress achieved during 1968-1973 in the German Black Pied popu...

Dufay, C., 1974: Ocneria prolai Htg. et Tephrina arenacearia Schiff. en Latium. (Lepidoptera Lymantriidae et Geometridae). Bollettino Soc Ent ltal, 1063-4: 75-77

Quan, L.; Wei, D.; Jiang, X.; Liu, Y.; Li, Z.; Li, N.; Li, K.; Liu, F.; Lai, L., 2008: Resurveying the Tris buffer solution: the specific interaction between tris(hydroxymethyl)aminomethane and lysozyme. An unusual phenomenon, the specific interaction between tris(hydroxymethyl)aminomethane (Tris) and lysozyme (LZM), was demonstrated for the first time by rapid screen analysis of interactions using a quartz crystal microbalance (QCM) biosensor. T...

Trivers, Robert; Manning, John; Jacobson, Amy, 2006: A longitudinal study of digit ratio (2D : 4D) and other finger ratios in Jamaican children. It has been hypothesised that the ratio between the length of the 2nd and 4th digits (2DAD) is a correlate of prenatal sex steroids, and this relationship is strongest for the right hand. Furthermore, it has been suggested that 2DAD is sexually di...

Schermer, S.; Kaempffer, A., 1936: Blood Groups in Horses. and K. discuss the characters and possible inheritance of the various cell and serum properties already described in horses, viz, the cell properties A and B and the corresponding serum properties a and beta , the occurrence of the properties A an...

Feschenko, M. S.; Sweadner, K. J., 1995: Structural basic for species specificity in phosphorylation of Na,K-ATPase by protein kinase C. Biophysical Journal 68(2 PART 2): A308

Diserbo, M.; Ziade, M.; Verdetti, J.; Fatome, M., 1995: PAF increases cytosolic free Ca-2+ concentrations in N1E-115 cells. This study first demonstrates that biologically relevant concentrations of PAF increases cytosolic free Ca-2+ concentrations ((Ca-2+)-i) in neuroblastoma cell line (clone N 1 E-115). This response results from the release of intracellular Ca-2+ st...

Orcel, Ph, 1999: Corticosteroid therapy and lung disease Prolonged systemic corticosteroid therapy Strategy for prevention and treatment of corticosteroid-induced osteoporosis. Revue des Maladies Respiratoires 16(SUPPL 3): 3S96-3S97, Jan

Fleisher, M.; Oettgen, H. F.; Besenfelder, E.; Schwartz, M. K., 1973: Measurement of carcino embryonic antigen. Clinical Chemistry 19(10): 1214-1220

Faraji Shadan F.; Stubbs J.D.; Bowman P.D., 1990: A putative approach for gene therapy against human immunodeficiency virus hiv. It is proposed here that a form of intracellular immunity can be devised which would protect cells from virus infection and, in particular, could be used as a treatment for the human immunodeficiency virus (HIV) infected individual. Following in v...