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Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase ec 2.7.1.40 isozymes and status of host lipids


, : Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase ec 2.7.1.40 isozymes and status of host lipids. Journal of the National Cancer Institute 73(6): 1311-1318

The histologic classification of mouse liver tumors, i.e., hepatic nodules type 1 and type 2 and hepatocellular carcinomas, was evaluated by a comparison of several biologic and biochemical markers that are useful for the grading of tumor malignancy. The liver tumors were induced by N,N'-2,7-fluorenylenebisacetamide (CAS: 304-28-9; N,N'-fluoren-2,7-ylenebisacetamide) administration to male CD-1 mice. The ability to induce L-type pyruvate kinase activity in response to a high carbohydrate diet disappeared in almost all the liver tumors. Fairly good correlations were observed between the histologic classification and the relative weight of liver and i.v. fat pads, between the histologic classification and the level of serum total cholesterol, and between the histologic classification and the K-type pyruvate kinase activity. This histologic classification evidently reflects the degree of tumor malignancy and therefore would be useful for the classification of mouse liver tumors.

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