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Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase ec isozymes and status of host lipids

, : Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase ec isozymes and status of host lipids. Journal of the National Cancer Institute 73(6): 1311-1318

The histologic classification of mouse liver tumors, i.e., hepatic nodules type 1 and type 2 and hepatocellular carcinomas, was evaluated by a comparison of several biologic and biochemical markers that are useful for the grading of tumor malignancy. The liver tumors were induced by N,N'-2,7-fluorenylenebisacetamide (CAS: 304-28-9; N,N'-fluoren-2,7-ylenebisacetamide) administration to male CD-1 mice. The ability to induce L-type pyruvate kinase activity in response to a high carbohydrate diet disappeared in almost all the liver tumors. Fairly good correlations were observed between the histologic classification and the relative weight of liver and i.v. fat pads, between the histologic classification and the level of serum total cholesterol, and between the histologic classification and the K-type pyruvate kinase activity. This histologic classification evidently reflects the degree of tumor malignancy and therefore would be useful for the classification of mouse liver tumors.

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Hammond, D. J.; Gutteridge, W. E., 1983: Studies on the glycosomal orotate phospho ribosyl transferase ec of trypanosoma cruzi. The orotate phosphoribosyltransferase of the epimastigote form of T. cruzi was studied in its particulate state in preparations derived from glycosomes. Maximum activity was observed at pH 9. There was little activity in the absence of Mg2+; optim...

Plyuoshch A. M.; Kadyrov N. K., 1970: Size of the geothermal gradient in the Siazan monocline. Doklady - Akademiya Nauk Azerbaydzhanskoy SSR = Me'ruzeler - Azerbaydzhan SSR Elmler Akademiyasy 26(10-11): 53-56

Gleason, Maurice, 2000: Paroxetine in the treatment of depression associated with withdrawal from heroin abuse and post-traumatic stress disorder. This invention relates to the use of paroxetine or a pharmaceutically acceptable salt thereof for the treatment of post-traumatic stress disorder and depression associated with withdrawal from heroin abuse.

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Duan Gang; Zhang Xi; Dai ZhiMing; Ge ChangRong; Gao ShiZheng, 2005: Effects of monoclonal antibody against adipocyte specific membrane protein on endocrine metabolism of porcine. Monoclonal antibody were injected intraperitoneally at 0.1, 0.5 and 1.0 mg/kg per body weight at 15 and 60 kg body weight. Serum insulin were lower in the treatment group than the control group. The contents of T3 (triiodothyronine), T4 (tetraiodo...

Baldwin, S. P., 1931: Bird-banding by systematic trapping. Scientific Publications Cleveland Museum, 1: 125-168

Zelzko, J. V., 1897: Beitrag zum Studium des Weissenberger Planers bei Neu-Straschitz. Verhandlungen der Geologischen Reichsanstalt, 173-176

Meszticzky, A., 1979: The position and potential of large livestock production operations. Systems of livestock husbandry, their economic situation, progress, main features and demands are described and particular systems are analyzed.

Barnes, Simon, A.; Quaggio, Ronaldo, B.; Chua, Nam-Hai, 1995: Phytochrome signal-transduction: Characterization of pathways and isolation of mutants. The study of phytochrome signalling has yielded a wealth of data describing both the perception of light by the receptor, and the terminal steps in phytochrome-regulated gene expression by a number of transcription factors. We are now focusing on...