EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase ec 2.7.1.40 isozymes and status of host lipids


Journal of the National Cancer Institute 73(6): 1311-1318
Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase ec 2.7.1.40 isozymes and status of host lipids
The histologic classification of mouse liver tumors, i.e., hepatic nodules type 1 and type 2 and hepatocellular carcinomas, was evaluated by a comparison of several biologic and biochemical markers that are useful for the grading of tumor malignancy. The liver tumors were induced by N,N'-2,7-fluorenylenebisacetamide (CAS: 304-28-9; N,N'-fluoren-2,7-ylenebisacetamide) administration to male CD-1 mice. The ability to induce L-type pyruvate kinase activity in response to a high carbohydrate diet disappeared in almost all the liver tumors. Fairly good correlations were observed between the histologic classification and the relative weight of liver and i.v. fat pads, between the histologic classification and the level of serum total cholesterol, and between the histologic classification and the K-type pyruvate kinase activity. This histologic classification evidently reflects the degree of tumor malignancy and therefore would be useful for the classification of mouse liver tumors.


Accession: 005395150



Related references

Evaluation of a histologic classification of mouse liver tumors based on pyruvate kinase isozymes and status of host lipids. Journal of the National Cancer Institute 73(6): 1311-1317, 1984

Biochemical characterization of 3 mutant isozymes of erythrocyte pyruvate kinase ec 2.7.1.40 pyruvate kinase gainesville pyruvate kinase san juan and pyruvate kinase cape canaveral. American Journal of Hematology 14(4): 335-344, 1983

Pyruvate kinase ec 27140 isozymes in various tissues of rat and increase of spleen type pyruvate kinase in liver by injecting chromatins from spleen and tumor. 1976

Pyruvate kinase isozymes in various tissues of rat, and increase of spleen-type pyruvate kinase in liver by injecting chromatins from spleen and tumor. Journal of Biochemistry 79(1): 203-215, 1976

Peptide structures of pyruvate kinase isozymes. I. Comparison of the four pyruvate kinase isozymes of the rat. Biochimica et Biophysica Acta 704(3): 484-493, 1982

Peptide structures of pyruvate kinase ec 2.7.1.40 isozymes 1. comparison of the 4 pyruvate kinase isozymes of the rat. Biochimica et Biophysica Acta 704(3): 484-493, 1982

Pyruvate kinase isozymes and dedifferentiation of (neuro-)ectodermal tumors. Tumour Biology 6(1): 75-87, 1985

Change of pyruvate kinase ec 2.7.1.40 isozymes in classical type pyruvate kinase deficiency and other pyruvate kinase deficiency cases during red cell maturation. American Journal of Hematology 16(1): 53-58, 1984

Isozymes of pyruvate kinase in liver and hepatomas of the rat. Cancer Research 34(6): 1439-1446, 1974

Pyruvate kinase isozymes in the liver during azo dye carcinogenesis. Igaku Kenkyu. Acta Medica 39(5): 393-405, 1969