+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a killed phase I Coxiella burnetii vaccine in cynomolgus monkeys (Macaca fascicularis)

, : Evaluation of a killed phase I Coxiella burnetii vaccine in cynomolgus monkeys (Macaca fascicularis). Laboratory Animal Science 31(1): 48-51

The protective efficacy of a killed, purified, phase I Coxiella burnetii vaccine was tested in cynomolgus monkeys. Monkeys vaccinated once with 30 micrograms of the antigen were challenged 6 or 12 months later with virulent phase I rickettsiae administered in small-particle aerosols. The vaccine provided only partial protection, since some of the challenged monkeys developed clinical signs of illness. However, the vaccinated animals did not develop pneumonia as determined by radiographic evaluation nor any hematologic or chemical changes except for an increase in fibrinogen. Although rickettsiae were isolated from peripheral blood in vaccinated monkeys, the rickettsemia persisted for only 1-2 days; whereas, organisms were recovered from unvaccinated animals for 6-7 days. All vaccinated animals had circulating microagglutinating antibodies to phase I and phase II antigens 6 and 12 months after vaccination.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005395163

PMID: 7253550

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Meulemans J.T.; Roos P.J., 1987: Production and decomposition in the emergent littoral zone of lake maarsseveen i the netherlands an overview. The emergent zone of Lake Maarsseveen I, which occupies 1.3% of the total surface area of the lake, is dominated by Phragmites australis. Growth characteristics of above ground structures of this reed are presented, as well as nutrient and carbon...

Mastropasqua, L.; Ciancaglini, M.; Di Tano, G.; Carpineto, P.; Lobefalo, L.; Loffredo, B.; Bosco, D.; Columbaro, M.; Falcieri, E., 1998: Ultrastructural changes in rat cornea after prolonged hypobaric hypoxia. A study was performed to evaluate the effect of prolonged environmental hypobaric hypoxia on the ultrastructure of rat cornea. 60-day-old female Wistar rats.were exposed to a simulated altitude of 5,500 m (350 mmHg) and pO2 of 76 mmHg for 30 days....

Modipalli, Lakshmi E.; Torgerson, Lorna J.; Hershenson, Marc B.; Phillippe, Mark; Lui, Pai; Schreiber, Michael D., 1998: The effect of prenatal cocaine exposure on myometrial alpha- and beta-adrenergic receptor kinetics and G-protein expression in guinea pigs. Pediatric Research 43(4 PART 2): 185A, April

Yun, J. I.; Lee, H. J., 1982: Effect of nitrogen fertilizer application on growth, forage yield and nitrogen use in Sudan grass. In trials in 1979-80 with Sudan grass given 0-800 kg N/ha annually, DM yield and LAI increased with up to 400 kg N in 1979 and 800 kg in 1980. Low temp. and solar radiation in 1980 led to lower yields than in 1979. Total N content in forage increa...

Vawter, M. P.; Tomita, T.; Evans, S.; Choudary, P.; Li, J.; Bolstad, B.; Meador Woodruff, J. H.; Lopez, J.; Speed, T.; Myers, R. M.; Watson, S.; Akil, H.; Jones, E. G.; Bunney, W. E., 2003: Bipolar and major depressive disorder gene expression profiling in three brain regions. American Journal of Medical Genetics 122B(1): 3-4, September 15

Stoffell Barry; Wilkinson J. J.; Jeffries T. E., 2004: Metal transport and deposition in hydrothermal veins revealed by 213nm UV laser ablation microanalysis of single fluid inclusions. 213nm UV laser ablation provides a powerful and cost-effective new method for the chemical microanalysis of individual fluid inclusions. The instrument offers significantly improved energy absorption in many geological materials compared to 266nm...

Robinson, M.W.; Hoey, E.M.; Fairweather, I.; Dalton, J.P.; McGonigle, S.; Trudgett, A., 2001: Characterisation of a beta-tubulin gene from the liver fluke, Fasciola hepatica. This study represents the first beta-tubulin sequence from a trematode parasite, namely, the liver fluke, Fasciola hepatica. PCR of genomic DNA showed that at least one beta-tubulin gene from F. hepatica contains no introns. A number of amino acid...

Michel B., 1990: Prion encephalopathies. Revue Neurologique (Paris) 146(1): 1-11

Anonymous, 2012: Assessing the utility of an anti-malarialpharmacokinetic-pharmacodynamic model foraiding drug clinical development. Mechanistic within-host models relating blood anti-malarial drug concentrations with theparasite-time profile help in assessing dosing schedules and partner drugs for new antimalarialtreatments. A comprehensive simulation study to assess the utili...

Vijay Kumar; Ray, N., 2000: Effect of plant growth regulators on cauliflower cv. Pant subhra. An experiment was carried out on cauliflower cv. Pant subhra to study the effect of different growth regulators. Thirty-day-old seedlings were transplanted into experimental plots and treated with 50 or 100 ppm GA3, 5 or 10 ppm IBA or 100 or 200 p...