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Evaluation of a killed rocky mountain spotted fever vaccine in cynomolgus monkeys macaca fascicularis

, : Evaluation of a killed rocky mountain spotted fever vaccine in cynomolgus monkeys macaca fascicularis. Journal of Clinical Microbiology 10(5): 719-723

A nonhuman primate model of Rocky Mountain spotted fever infection was developed in cynomolgus monkeys infected s.c. or by aerosol. Clinical responses, hematology and serum chemistry values, and pathological findings were similar to those found in humans with Rocky Mountain spotted fever. The clinical model was then used to test the efficacy of a killed Rocky Mountain spotted fever vaccine grown in chicken embryo cells. Monkeys were immunized with varying dilutions of the vaccine with a 2-dose schedule and then challenged at 2 mo. with virulent Rickettsia rickettsii s.c. or by aerosol. The undiluted vaccine totally protected monkeys against both challenges even at extremely high doses.

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