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Evaluation of a method of production and purification of monoclonal antibodies for clinical applications

, : Evaluation of a method of production and purification of monoclonal antibodies for clinical applications. Journal of Immunological Methods 102(2): 187-194

A procedure is described for the purification of monoclonal antibodies (Mab) from ascitic fluids, which meets the quality control required for in vivo applications of immunoglobulins (Ig) in man. Additional assays were performed to calculate viral and DNA content of the purified Mab. These studies are important the possible side effects, oncogenic events and virus-related diseases which could follow immunotherapy with Mab.

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Accession: 005395236

PMID: 3655372

DOI: 10.1016/0022-1759(87)90076-7

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