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Evaluation of a monoclonal IgM antibody for purging of bone marrow for autologous transplantation


, : Evaluation of a monoclonal IgM antibody for purging of bone marrow for autologous transplantation. Bone Marrow Transplantation 1(3): 297-301

A monoclonal antibody of the IgM class, reacting with the CD9 (p24) antigen is described. The antibody (FMC27) is cytotoxic against cells of the common type of acute lymphoblastic leukaemia (c-ALL), giving killing at higher dilutions than an IgG antibody (FMC8) against the same antigen. FMC27 and FMC8 recognise different epitopes, and FMC27 may thus be used in a cocktail together with FMC8 and an antibody against the c-ALL antigen, WM21. Furthermore, the IgM antibody can be coated directly onto magnetic microparticles for magnetic purging, unlike the IgG antibody which must be used in a two-layer procedure.

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Accession: 005395291

PMID: 3332140

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Liang G Y.; Gray A.I.; Thomas D.W.; Waterman P.G., 1988: Polyoxygenated cyclohexane epoxide derivatives from the stem bark of monanthotaxis buchananii. From the stem bark of Monanthotaxis buchananii five oxygenated cyclohexane epoxide derivatives have been isolated, four of which are novel. One was identified as the 2-methyl ether of (+)-pipoxide and a second as 1.alpha.-benzoyloxymethyl-3.alpha....

Hagsten, I.; Perry, T. W., 1976: Evaluation of dietary salt levels for swine. 2. Effect on blood and excretory patterns. 2. In 6 experiments feeding and watering for 81 growing crossbred barrows was as described in the preceding abst. Packed cell volume (PCV), excretion of Na and K and N in urine and faeces were studied. PCV decreased with up to 0.14% added salt, th...

Bornert, G.; Leroux, D.; Bouhda, Y., 2001: Behaviour of Listeria monocytogenes in salads packed in small trays in a modified atmosphere. 200 g samples of various salads were inoculated experimentally with L. monocytogenes and then stored for 15 days at 4 degrees C in an atmosphere of 70% nitrogen and 30% carbon dioxide. Numbers of the bacteria decreased considerably after 4-9 days...

Anonymous, 1981: First colloquium on fruit research, Bordeaux. This colloquium was organised jointly by the Institut National de la Recherche Agronomique and the Centre Technique Interprofessionnel des Fruits et Legumes. Of the 25 papers presented at the meeting, 23 reflect current French research on apples,...

Better J.; Gatenbeck S., 1979: The enzymic reductions of aryl aldehydes and aryl alcohols in penicillium baarnense. The ability of whole cells of P. baarnense to reduce aryl-aldehydes and aryl-alcohols to the corresponding methyl derivatives was shown. Cell-free experiments show that 2 separate enzymes, an aryl-alcohol dehydrogenase and an aryl-alcohol reductas...

Diehl, Beate; Lapresto, Eric; Najm, Imad; Raja, Shanker; Rona, Sabine; Babb, Thomas; Ying, Zhong; Bingaman, William; Luders, Hans O.; Ruggieri, Paul, 2003: Neocortical temporal FDG-PET hypometabolism correlates with temporal lobe atrophy in hippocampal sclerosis associated with microscopic cortical dysplasia. Purpose: Medically intractable temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS), with or without cortical dysplasia (CD), is associated with atrophy of the hippocampal formation and regional fluorodeoxyglucose positron-emission tomog...

Albaum, S.; Masaphy, S., 2009: Comparison of rose bengal-chloramphenicol and modified aureomycin-rose bengal-glucose-peptone agar as media for the enumeration of molds and yeasts in water by membrane filtration techniques. The present study compares the suitability of rose bengalchloramphenicol (RBCh) and modified aureomycin-rose bengal glucose-peptone agar for enumerating fungi recovered from diverse water sources using the membrane filtration method. Both mold and...

Ochi, Kazuhide; Kohriyama, Tatsuo; Higaki, Masahiro; Ikeda, Junko; Harada, Akira; Nakamura, Shigenobu, 2003: Changes in serum macrophage-related factors in patients with chronic inflammatory demyelinating polyneuropathy caused by intravenous immunoglobulin therapy. Chronic inflammatory demyelinating polyneuropathy (CIDP) is a slowly progressive or recurrent neuropathy accompanied by infiltration of macrophages in the peripheral nerves. Macrophage colony-stimulating factor (M-CSF) and monocyte chemoattractant...

Rhoads Donald C.; Boyer Larry F., 1982: The effects of marine benthos on physical properties of sediments; a successional perspective. 2; Pages 3-52:

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