EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a monoclonal IgM antibody for purging of bone marrow for autologous transplantation


Bone Marrow Transplantation 1(3): 297-301
Evaluation of a monoclonal IgM antibody for purging of bone marrow for autologous transplantation
A monoclonal antibody of the IgM class, reacting with the CD9 (p24) antigen is described. The antibody (FMC27) is cytotoxic against cells of the common type of acute lymphoblastic leukaemia (c-ALL), giving killing at higher dilutions than an IgG antibody (FMC8) against the same antigen. FMC27 and FMC8 recognise different epitopes, and FMC27 may thus be used in a cocktail together with FMC8 and an antibody against the c-ALL antigen, WM21. Furthermore, the IgM antibody can be coated directly onto magnetic microparticles for magnetic purging, unlike the IgG antibody which must be used in a two-layer procedure.


Accession: 005395291

PMID: 3332140



Related references

Monoclonal antibody and complement mediated purging of bone marrow for autologous bone marrow transplantation in acute myeloblastic leukemia. Journal of Cellular Biochemistry Supplement (12 PART C): 65, 1988

Combined lectin/monoclonal antibody purging of bone marrow for use in conjunction with autologous bone marrow transplantation in the treatment of multiple myeloma. Methods in Molecular Medicine 9: 351-361, 1998

Autologous bone-marrow transplantation for Burkitt's lymphoma: marrow purging with anti-Y 29/55 monoclonal antibody and complement. Iarc Scientific Publications: 435-440, 1985

Monoclonal antibody purging and autologous bone marrow transplantation in acute myelogenous leukemia in complete remission. Bone Marrow Transplantation 4(6): 669-674, 1989

Autologous bone marrow transplantation for leukemia: monoclonal antibody-mediated purging of multidrug-resistant leukemia. Leukemia Research 17(6): 491-499, 1993

Autologous bone marrow transplantation for leukemia: Monoclonal antibody-mediated purging of multidrug-resistant leukemia. Leukemia Research 17(6): 491-499, 1993

Purging of bone marrow with the monoclonal anti calla antibodies vil a 1 vib e 3 and vib c 5 as a prerequisite for autologous bone marrow transplantation. Experimental Hematology (Charlottesville) 13(SUPPL 17): 54, 1985

In vitro purging of bone marrow for autologous marrow transplantation in acute myelogenous leukemia using myeloid-specific monoclonal antibodies. Bone Marrow Transplantation 3(5): 387-392, 1988

Purging of bone marrow with a cocktail of monoclonal antibodies (VIB-pool) for autologous transplantation. Haematology and Blood Transfusion 31: 89-91, 1987

Monoclonal antibody purging of bone marrow using campath 1 and ucht 1 for matched and mismatched family allogeneic bone marrow transplantation. Experimental Hematology (Charlottesville) 13(SUPPL 17): 112-113, 1985