EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a new beta adrenoceptor agonist procaterol based on metabolic responses in rats


, : Evaluation of a new beta adrenoceptor agonist procaterol based on metabolic responses in rats. Biochemical Pharmacology 27(21): 2531-2536

I.v. injection of 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxycarbostyril hydrochloride hemihydrate (procaterol) or isoproterenol into fasted rats caused increases in blood levels of glucose, lactate, free fatty acids (FFA), glycerol, immunoreactive insulin and cAMP. Procaterol-induced alterations of these metabolic parameters, other than FFA, were durable; the increases were observable over a period longer than 2 h, in contrast to a much shorter duration of isoproterenol-induced metabolic changes. These actions of procaterol were antagonized by propranolol, were observed in adrenodemedullated rats, and were enhanced by theophylline. Metabolic changes induced by procaterol might actually be mediated via .beta.-adrenoceptors as well as its pharmacological actions. Procaterol caused hyperlactacidemia at M doses 10-100 times lower than those required for isoproterenol, trimetoquinol or salbutamol. A much higher dose of procaterol was required to increase blood levels of FFA, glycerol and insulin. Butoxamine, a selective .beta.2-adrenoceptor antagonist, antagonized the isoproterenol-induced blood lactate, while practolol, a selective .beta.1-antagonist, effectively inhibited the stimulatory actions of isoproterenol on FFA, glycerol and insulin. Procaterol was a more selective .beta.2-adrenoceptor agonist than isoproterenol or trimetoquinol and was more potent than salbutamol.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005395340

PMID: 31885

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Herman, L.L.; Kurtz, R.C.; Brennan, M.F.; Shike, M., 1992: Acute pancreatitis from intussusception of a gastric polyp in a patient with Gardner's syndrome. Gastric polyps in Gardner's syndrome are usually benign small fundic gland neoplasms with little clinical significance. We report a case of gastroduodenal intussusception secondary to a large benign gastric polyp in a 44-year-old woman with G...

Power, A.E.; Vazdarjanova, A.; McGaugh, J.L., 2003: Muscarinic cholinergic influences in memory consolidation. The central cholinergic system and muscarinic cholinergic receptor (mR) activation have long been associated with cognitive function. Although mR activation is no doubt involved in many aspects of cognitive functioning, the extensive evidence that...

Kawakubo, K.; Tada, M.; Isayama, H.; Sasahira, N.; Nakai, Y.; Takahara, N.; Uchino, R.; Hamada, T.; Miyabayashi, K.; Yamamoto, K.; Mizuno, S.; Mohri, D.; Kogure, H.; Sasaki, T.; Yamamoto, N.; Hirano, K.; Ijichi, H.; Tateishi, K.; Koike, K., 2014: Disease-specific mortality among patients with intraductal papillary mucinous neoplasm of the pancreas. Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is associated with synchronous and metachronous pancreatic cancer. However, the risk factors for pancreatic cancer-specific mortality have not been determined. We evaluated disease-spe...

Deberdt, R., 1968: Rehbilitation of motor handicapped children. Experience at the Gits Institute (Belgium). Journal des Sciences Medicales de Lille 86(4): 245-247

Gordon P.R.; O'dell B.L., 1979: Effect of short term zinc deficiency on hemostasis in the rat. Federation Proceedings 38(3 PART 1): 605

Abu-Elmagd, K.M.; Zak, M.; Stamos, J.M.; Bond, G.J.; Jain, A.; Youk, A.O.; Ezzelarab, M.; Costa, G.; Wu, T.; Nalesnik, M.A.; Mazariegos, G.V.; Sindhi, R.K.; Marcos, A.; Demetris, A.J.; Fung, J.J.; Reyes, J.D., 2004: De novo malignancies after intestinal and multivisceral transplantation. Background. Maintenance immunosuppression required after organ transplantation creates a permissive environment in which cancer cells can proliferate because of lack of natural immunologic surveillance. With more than a decade of clinical experien...

Rozencweig, D., 1983: Temporomandibular joint pain-dysfunction syndrome: myths and realities. Revue D'odonto-Stomatologie 12(4): 269-276

Gutric, M.; Monod, O., 1970: Une serie mesozoique condenses dans les nappes du Taurus occidental: la serie du Boyali Tepe. C.r. Somm. Seanc. Soc. geol. Fr.: 166-167

Bruster, B.E.; Adalist-Estrin, A., 2012: The impact of parental incarceration on children and families. Introduction. Social Work in Public Health 27(1-2): 1-2

Metwally, F.H.; Abdelkawy, M.; Naguib, I.A., 2006: Determination of nifuroxazide and drotaverine hydrochloride in pharmaceutical preparations by three independent analytical methods. Three new, different, simple, sensitive, and accurate methods were developed for quantitative determination of nifuroxazide (I) and drotaverine hydrochloride (II) in a binary mixture. The first method was spectrophotometry, which allowed determina...