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Evaluation of a new fecal occult blood testing


, : Evaluation of a new fecal occult blood testing. Journal of Kyoto Prefectural University of Medicine 95(10): 1331-1338

The incidence of colorectal cancer is increasing in Japanese, and several trials for its early detection have been conducted. Fecal occult blood testing has been proved to be useful in the mass screening of colorectal cancer. New methods based on immunological reaction have recently been developed, which exclusively detect human hemoglobin in the stool. In this paper, we evaluated the usefulness of the new fecal occult blood testing (OC-Hemodia-Eiken), which is based on latex agglutination reaction, in the detection of colorectal cancer. Three days consecutive testing was carried out in 30 cases with colorectal cancer, 35 cases with colorectal polyp, 8 cases with gastric cancer and 137 normal subjects. Positive results were obtained in 100% of colorectal cancer, 42.9% of colorectal polyp and 37.5% of gastric cancer. False positive ratio in the normal subjects was low (5.1%). These data show that the new method is superior in both sensitivity and specificity to other immunological fecal occult blood tests using enzyme immunoassay. While other immunological tests are technically complicated, this new test is rather easy and time-sparing. Considering these advantages, OC-Hemodia-Eiken is expected to be useful in the mass screening of colorectal cancer.

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