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Evaluation of a new latex agglutination method for detection of antibody to herpes simplex virus


, : Evaluation of a new latex agglutination method for detection of antibody to herpes simplex virus. Journal of Clinical Microbiology 26(5): 1024-1025

A new latex agglutination (LA) test (Wampole Laboratories, Cranbury, N.J.) for detection of antibody to herpes simplex virus was compared with a reference complement fixation (CF) method in a premarket evaluation. Of 102 serum samples tested, 19 were LA negative and CF negative, 79 were LA positive and CF positive, and 4 were LA positive and CF negative. An enzyme immunoassay (M. A. Bioproducts, Walkersville, Md.) performed on the four LA-positive and CF-negative serum samples agreed with LA in all cases. Most LA titers were two to four doubling dilutions higher than CF titers. We conclude that this new LA test is a rapid, sensitive, and simple method for documentation of past infection with herpes simplex virus.


Accession: 005395388

PMID: 2838501

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Related references

Landgraf J.; Gerrity M.; Aquino T., 1988: Evaluation of a latex agglutination test for detection of herpes simplex virus in cell culture. American Journal of Clinical Pathology 89(3): 448

López-Medrano, R.; García-Bravo, M.; Pedraza, M.A.; Otero, J.R., 1992: Evaluation ofa latex (Virogen, Wampole) agglutination test for rapid detection of herpes simplex virus in clinical samples. Enfermedades Infecciosas Y Microbiologia Clinica 10(3): 178-179

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Killian C.S., 1987: Evaluation of a latex agglutination assay for anti herpes simplex antibodies. SACM (Southern Association for Clinical Microbiology) Review 12(1): 8-9

Gleaves, C.A.; Meyers, J.D., 1988: Determination of patient herpes simplex virus immune status by latex agglutination. A rapid latex agglutination (LA) test was compared with complement fixation and enzyme immunoassay for the determination of herpes simplex virus immune status in sera of patients. Of 173 samples, 88% gave concordant results in all three assays (11...