+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a novel antihypertensive agent ly 127210 7 8 dimethoxy 1h 3 benzazepin 2 amine hydrochloride in anesthetized and conscious spontaneously hypertensive rats

, : Evaluation of a novel antihypertensive agent ly 127210 7 8 dimethoxy 1h 3 benzazepin 2 amine hydrochloride in anesthetized and conscious spontaneously hypertensive rats. Journal of Pharmacology & Experimental Therapeutics 232(1): 134-138

LY127210 is a novel peripheral arterial vasodilator that reduces mean arterial blood pressure in anesthetized and conscious spontaneously hypertensive rats by all conventional routes of administration. The antihypertensive activity of LY127210 results predominantly from a decrease in total peripheral vascular resistance, and to a degree of reflex tachycardia produced by LY127210 in conscious spontaneously hypertensive rats is significantly less than that produced by hydralazine at equivalent antihypertensive doses. The relative lack of reflex tachycardia produced by LY127210 appears to result from a direct bradycardic effect of the compounds that occurs at the level of the myocardium at doses similar to those required to produce peripheral arteriolar vasodilation. Apparently the direct bradycardic effect of LY127210 serves to offset, at least in part, the tachycardia resulting from reflex stimulation of sympathetic outflow that occurs on activation of the baroreflex loop as blood pressure is lowered. LY127210 may provide adequate control of blood pressure and may not require the concomitant administration of a .beta.-adenoceptor antagonist to control reflex tachycardia, as is commonly necessary with hydralazine.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005395468

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Ahmad, A. A.; Al Rimawi, F.; Khalili, F. I.; Mubarak, M. S., 2005: Chelation properties of some condensation polymers toward some trivalent lanthanide ions. The sorption properties of some condensation polymers: poly(galic acid-2,6-diylmethylene), polymer I, poly(piperazine-1,4-diylmethylene), polymer II, and poly(catechol-3,6-diylmethylene), polymer III, toward the trivalent lanthanide metal-ions, La...

Huijbers W.A.R.; Oosterbaan J.A.; Meskendorp Haarsma T.J.; Hardonk M.J.; Molenaar I., 1979: An ultrastructural and cytochemical study of membrane alterations in x irradiated liver tissue from normal and vitamin e deficient ducklings. An investigation into the differential susceptibility of liver cellular membranes to peroxidative processes was performed, using X irradiation on the liver surface, resulting in a 3-mm penetrating gradient of membrane damage. Ultrastructural, cyto...

Zeevaart, Jan A. D., 1964: Chemical basis of induction induction. The notion that steroid hormones function as regulators of gene action is generally attractive, but difficult to implement specifically. There are 2 particularly difficult points. The steroid hormones appear to interact most strongly with denature...

Sheikh, Farah; Sontag, David P.; Fandrich, Robert R., 2001: Overexpression of FGF-2 increases cardiac myocyte viability after injury in isolated mouse hearts. Farah Sheikh, David P. Sontag, Robert R. Fandrich, Elissavet Kardami, and Peter A. Cattini Overexpression of FGF-2 increases cardiac myocyte viability after injury in isolated mouse hearts. Am J Physiol Heart Circ Physiol 280: H1039-H1050, 2001.--...

Filippini, L., 1983: Input-output analysis and food industry. Annali Facolta di agraria 23(1): 85-134

Wagner, Luciane-Carniel; De-Almeida-Fleck, Marcelo-Pio; Wagner, Mario; Guterres-Dias, Miriam-Thais, 2006: Autonomy of long-stay psychiatric inpatients. OBJECTIVE: To assess personal autonomy of long-stay psychiatric inpatients, to identify those patients who could be discharged and to evaluate the impact of sociodemographic variables, social functioning, and physical disabilities on their autono...

Duke, G. E.; Kuhlmann, W. D.; Fedde, M. R., 1977: Evidence for mechano receptors in the muscular stomach of the chicken. Single-fiber, vagal recordings were made from mechanoreceptors in the muscular stomach of the chicken. These receptors increased discharge frequency during gentle compression of the wall of this organ and when coordinated contractions of the organ...

Austin H. Kutscher; Jack Budowsky; Stanley L. Lane; Neal W. Chilton, 1953: Reactions following the use of aureomycin and procaine penicillin troches A controlled study. Journal of Allergy (-1970 Elsevier Science) 24(2): 0-171

Ingram M., 1971: Hematological basis for the evaluation of radiation exposure low level long term exposures and late effects. International Atomic Energy Agency And World Health Organization International Atomic Energy Agency Technical Reports Series, No 123 Manual on Radiation Haematology 430p Illus Unipub, Inc : New York, N Y , U S A 265-275

Fauck, R., 1954: First observations on the relationships between green manure and chemical manures in Middle Casamence.. Groundnut yields decreased the second year in spite of application of mineral fertilizer. This is probably due to degradation of soil structure and decrease in humus content. Green manuring improved the humus content and thus improved the soil abs...