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Evaluation of a procedure to measure the time course of a drug's behavioral action

Journal of Pharmacological Methods 20(2): 169-174
Evaluation of a procedure to measure the time course of a drug's behavioral action
The utility of a novel procedure to examine a drug's time course of behavioral action was evaluated. Time- and dose-effect relations for the antiepilepsy drug methsuximide were determined in pigeons during 12-hr overnight sessions through the use of a multiple variable-interval 60-sec extinction (mult VI EXT) schedule of food delivery. The VI 60-sec components were programmed for the first 10 min of each hour and were followed by 50-min EXT components. Methsuximide produced dose-dependent decreases in rate of responding; the higher the dose, the longer the duration of efffect. The present procedure appears to be useful for determining effective pression injection intervals and time-effect relations.

Accession: 005395527

PMID: 3221680

DOI: 10.1016/0160-5402(88)90077-0

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