+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a procedure to measure the time course of a drug's behavioral action

, : Evaluation of a procedure to measure the time course of a drug's behavioral action. Journal of Pharmacological Methods 20(2): 169-174

The utility of a novel procedure to examine a drug's time course of behavioral action was evaluated. Time- and dose-effect relations for the antiepilepsy drug methsuximide were determined in pigeons during 12-hr overnight sessions through the use of a multiple variable-interval 60-sec extinction (mult VI EXT) schedule of food delivery. The VI 60-sec components were programmed for the first 10 min of each hour and were followed by 50-min EXT components. Methsuximide produced dose-dependent decreases in rate of responding; the higher the dose, the longer the duration of efffect. The present procedure appears to be useful for determining effective pression injection intervals and time-effect relations.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005395527

PMID: 3221680

DOI: 10.1016/0160-5402(88)90077-0

PDF Full Text: Evaluation of a procedure to measure the time course of a drug's behavioral action

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Abel, T.W.lliam; Rance, N.E.len, 2000: Stereologic study of the hypothalamic infundibular nucleus in young and older women. Aging in women is associated with dramatic changes in neuronal morphology and neuropeptide gene expression in the medial basal hypothalamus. There is hypertrophy of neurons expressing substance P and neurokinin B gene transcripts in the infundibul...

MacLean, DB., 1978: Seasonal and spatial variation of species diversity in collections of Scarabaeidae, Elateridae and Cerambycidae from west central Indiana. Proceedings of the Indiana Academy of Science, 87: 252-258

Munro, J. M., 1968: Controls in a series of field experiments. With reference to cotton trials, the need for reliable control varieties, the estimation of missing values for varieties omitted from some trials, the use of multiple controls and the estimation of control yield from the other varieties in trial a...

Anonymous, 2011: Veterinary researcher receives prestigious grant to study swine disease. A researcher in the Virginia-Maryland Regional College of Veterinary Medicine has received a prestigious US Department of Agriculture postdoctoral fellowship grant to investigate the molecular mechanisms of pathogenesis behind porcine reproductive...

Karle, I.L.; Urry, D.W., 2005: Crystal structure of cyclic (APGVGV)2, an analog of elastin, and a suggested mechanism for elongation/contraction of the molecule. Tropoelastin is a complex polymeric protein composed primarily of repeating segments of Val-Pro-Gly-Gly, Val-Pro-Gly-Val-Gly, and Ala-Pro-Gly-Val-Gly-Val that occurs in connective tissue and arteries. It has rubber-like extensible properties. A sy...

MOSES.R.A.; BECKER.B., 1958: Clinical tonography; the scleral rigidity correction. American Journal of Ophthalmology 45(2): 196-208

Weist, M.D.; Goldstein, J.; Evans, S.W.; Lever, N.A.; Axelrod, J.; Schreters, R.; Pruitt, D., 2003: Funding a full continuum of mental health promotion and intervention programs in the schools. To assess the availability of public and private financing sources to support comprehensive school mental health programs. The paper focuses on "expanded school mental health" (ESMH) programs, which provide a full array of mental health...

Coultas, J., 1983: Crop competition with wild proso millet in Minnesota. Soils Fertilizer and Agricultural Pesticides Short Course: proceedings: December 13-14-1983 presented by the University of Minnesota Institute of Agriculture Forestry and Home Economics et al: 07

Anonymous, 2002: Pharmacist-driven DM effort relies on predictive data combined with modest intervention. Given the high number of patients who fail to take their medicines as directed, there is a strong case to be made that pharmacists could play a much stronger role in DM efforts. Now, Costa Mesa, CA-based Prescription Solutions is testing that theo...

Ranne, J.O.; Sarimo, J.J.; Heinonen, O.J.; Orava, S.Y., 2014: A combination of Latarjet and Remplissage for treatment of severe glenohumeral instability and bone loss. A case report. Recurrent glenohumeral instability is challenging to treat when large bony defects are present in the anterior glenoid and there is a large Hill-Sachs lesion. We present a case with extensive glenoid and humeral bone loss treated with open Latarje...