+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a proposed method for phenytoin maintenance dose prediction following an intravenous loading dose

, : Evaluation of a proposed method for phenytoin maintenance dose prediction following an intravenous loading dose. European Journal of Clinical Pharmacology 32(2): 141-148

A large clinical study, designed to investigate the induction of theophylline metabolism by phenytoin, provided the opportunity to test a previously proposed method for estimating dose requirements of phenytoin. This method involves prediction of the oral maintenance dosage from data obtained following the administration of an intravenous loading dose. In 30 subjects, trough plasma concentration at steady-state were 12.0 .+-. 4.9 .mu.g .cntdot. ml-1 (mean .+-. SD) and differed by -2.7 .+-. 39.3% from a mean target plasma concentration of 12.5 .+-. 1.5 .mu.g .cntdot. ml-1. A Bayesian regression programme was used to forecast an estimate of each subject's individual pharmacokinetics. These were then used to predict the steady-state plasma concentrations which would be expected from the use of this standard dosage, the proposed method gave acceptable steady-state plasma phenytoin concentrations with significant reductions in deviations from target concentrations. This method for the rapid individualization of phenytoin dosage requirements provides an improvement over more traditional methods of choosing an arbitary dose adjusted for body weight followed by dosage adjustments based on achieved plasma concentration.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005395536

PMID: 3582477

DOI: 10.1007/bf00542186

PDF Full Text: Evaluation of a proposed method for phenytoin maintenance dose prediction following an intravenous loading dose

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references; J.S.nder; Ch. Kottmeier, 2009: Recent trends of thunderstorm and hailstorm frequency and their relation to atmospheric characteristics in southwest Germany. In the context of climate change, it is of particular interest whether extreme events connected to severe thunderstorms have been increasing in number or intensity over the past few decades. Due to their small horizontal extent, such events are no...

Arif, H.; Shaaban, S.; Rashwan, H., 1998: A technique for ureterosigmoidostomy by direct interposition of an ileal loop with a valve. British Journal of Urology 81(1): 156-158

Bossa, F.B.rra, D., 1974: Identification of amino acid residues in the active center of soluble aspartate aminotransferase from pig heart. Acta vitaminologica et enzymologica: 8 (6) 253-257

Davies David K.; Ethridge Frank G., 1971: Claiborne group of central Texas; record of middle Eocene marine coastal plain deposition. The American Association of Petroleum Geologists Bulletin 55(9): 1693

Chantrelle B.; Cogan M.G.; Rector F.C.Jr, 1979: Relation of sodium transport and acidification in the rat proximal convoluted tubule. Kidney International 16(6): 809

Shiomi, T.; Tsutsui, H.; Matsusaka, H.; Murakami, K.; Hayashidani, S.; Ikeuchi, M.; Wen, J.; Kubota, T.; Utsumi, H.; Takeshita, A., 2004: Overexpression of glutathione peroxidase prevents left ventricular remodeling and failure after myocardial infarction in mice. Background: Oxidative stress plays an important role in the pathophysiology of heart failure. We determined whether the overexpression of glutathione peroxidase (GSHPx) could attenuate left ventricular (LV) remodeling and failure after myocardial...

Weiner K.L.; Hochleitner R., 1981: Index sheet; apophyllite. Lapis (Muenchen) 6(3): 5-7

Vella, A.; de Groen, P.C.; Dinneen, S.F., 1998: Fatal hepatotoxicity associated with troglitazone. Annals of Internal Medicine 129(12): 1080-1080

Schwarzbach, M.H.; Dimitrakopoulou-Strauss, A.; Mechtersheimer, G.; Hinz, U.; Willeke, F.; Cardona, S.; Attigah, N.; Strauss, L.G.; Herfarth, C.; Lehnert, T., 2002: Assessment of soft tissue lesions suspicious for liposarcoma by F18-deoxyglucose (FDG) positron emission tomography (PET). F18-deoxyglucose (FDG) positron emission tomography (PET) is a promising imaging technique. The aim of this study was to investigate the use of FDG PET in patients with suspected liposarcomas (LS). Forty-two masses were studied. The FDG uptake was...

Malishevskii, N. M., 1977: Suitable timber drying regimes for use in musical instrument manufacture. Drying regimes are recommended that reduce the amount of residual tension after seasoning of spruce, maple, hornbeam and pear [Pyrus] sawn timber. The regimes were derived on the basis of measurements of initial tension by a method described earli...