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Evaluation of a rat model for assessing interventions to salvage ischemic myocardium effects of ibuprofen and verapamil


, : Evaluation of a rat model for assessing interventions to salvage ischemic myocardium effects of ibuprofen and verapamil. Cardiovascular Research 19(3): 132-138

Coronary ligated rats were administered i.p. injections of 6.24, 12.52 and 25.00 mg .cntdot. kg-1 ibuprofen and 5.00 and 10.00 mg .cntdot. kg-1 verapamil 1 h before ligation, 1 h after ligation, and then every 8 h for 48 h. Ibuprofen at 50.00 mg .cntdot. kg-1 was administered 1 h before ligation, 1 h after ligation and 5 h ligation. Infarct size was determined either by weighing the stained excised infarcted area or by measuring the creatine kinase activity from the excised left ventricle. Ibuprofen and verapamil treatment resulted in less myocardial damage after 48 h than placebo treatment, but the differences were generally not statistically significant. The reduction in infarct size was greater in the ibuprofen, treated animals than in the verapamil-treated rats. There was a lower mortality with ibuprofen treatment than with verapamil or placebo. This rat model was useful as a screening tool for the initial evolution of therapeutic interventions to reduce myocardial infarct size. It requires substantially less time than large animal models and can be used to examine a variety of treatment doses. These experiments also demonstrated the importance of randomization to treatment and control groups because of the possibility of disproportionate mortality affecting infarct size.

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