EurekaMag.com logo
+ Translate

Evaluation of a rat model for assessing interventions to salvage ischemic myocardium effects of ibuprofen and verapamil


, : Evaluation of a rat model for assessing interventions to salvage ischemic myocardium effects of ibuprofen and verapamil. Cardiovascular Research 19(3): 132-138

Coronary ligated rats were administered i.p. injections of 6.24, 12.52 and 25.00 mg .cntdot. kg-1 ibuprofen and 5.00 and 10.00 mg .cntdot. kg-1 verapamil 1 h before ligation, 1 h after ligation, and then every 8 h for 48 h. Ibuprofen at 50.00 mg .cntdot. kg-1 was administered 1 h before ligation, 1 h after ligation and 5 h ligation. Infarct size was determined either by weighing the stained excised infarcted area or by measuring the creatine kinase activity from the excised left ventricle. Ibuprofen and verapamil treatment resulted in less myocardial damage after 48 h than placebo treatment, but the differences were generally not statistically significant. The reduction in infarct size was greater in the ibuprofen, treated animals than in the verapamil-treated rats. There was a lower mortality with ibuprofen treatment than with verapamil or placebo. This rat model was useful as a screening tool for the initial evolution of therapeutic interventions to reduce myocardial infarct size. It requires substantially less time than large animal models and can be used to examine a variety of treatment doses. These experiments also demonstrated the importance of randomization to treatment and control groups because of the possibility of disproportionate mortality affecting infarct size.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005395626

PMID: 3986856

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Bromberg, J.F.; Wrzeszczynska, M.H.; Zhao, Y.; Darnell, J.E.Jr, 2001: Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes. The invention is directed to constitutively active Stat proteins and methods for their preparation. The modified Stat proteins have at least one cysteine residue which may interact with the corresponding cysteine residue on another modified Stat p...

Deutsch, D.W., 2005: 10 rules for the retirement road. Hawaii Dental Journal 36(1): 11-13

Liu, K.J.; Shi, X.; Dalal, N.S., 1997: Synthesis of Cr(IV)-GSH, its identification and its free hydroxyl radical generation: a model compound for Cr(VI) carcinogenicity. Current models of Cr(VI) carcinogenesis suggest an important role for Cr(IV) as an intermediate, toxic, carcinogenic species, but direct chemical evidence has been lacking. This is because Cr(IV) is a highly reactive oxidation state of Cr and few...

Stepkowski, S.M., 2003: Preclinical results of sirolimus treatment in transplant models. Sirolimus (SRL; rapamycin) is a macrolide antibiotic, which modest anticandidal and tumoricidal activities were superseded by its immunosuppressive potential to block allograft rejection. The most intriguing biological characteristic of SRL emerge...

Merenkova, Irena N., 2004: Analysis of nucleotide polymorphisms at a site. The identity of the polymorphic nucleotide in a target sequence having at least two known variants can be easily and efficiently detected by hybridizing at least one primer upstream of the biallelic marker and performing extension reactions using...

Lyapunova, E.A.; Bunch, T.D.; Vorontsov, N.N.; Hoffman, R.S., 1997: Chromosomal complement and taxonomic position of Severtsov wild sheep. A review of the genus Ovis taxonomy indicates that the position of Severtsov wild sheep from the Nura-Tau mountains (Kyzyl-Kum desert) is unclear. Its range falls between urial sheep (O. vignei, 2n = 58) and arkhar sheep (O. ammon, 2n = 56). A spe...

Tsai, I.L.h; Wu, S.J.n; Ishikawa, T.; Seki, H.; Yan, S.T.ng; Chen, I.S.eng, 1995: Evomerrine from Melicope semecarpifolia. A new phenolic furoquinoline alkaloid, evomerrine, was isolated from the leaves of Melicope semecarpifolia. Its structure was elucidated from spectral data and chemical evidence. Six other known furoquinoline alkaloids, platydesmine, skimmianine,...

Makambila, C., 1977: Growth correlations and morphogenesis of the thallus of Rosellinia species. Trophic correlations were found between the surface mycelium and intramatrical hyphae. Inhibition of hyphal growth stimulated rhizomorph formation. Autonomous growth of isolated rhizomorphs did not occur. The hormonal influence of the mycelium is...

Anonymous, 2011: An alternative approach towards assessing of and accounting for individual motion in fMRI timeseries. Motion is a significant problem for the analysis of functional MRI data. This manuscript addresses the question of whether an individualized assessment of motion may be informative, and whether it may be beneficial with regard to explaining motion...

Kaneshiro, Y., 1976: Nature of nursing observed in clinical nursing--clinical training in nursing of a case of bronchial asthma. Nursing Technique 22(3): 107-119