EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of a role for phosgene production in the hepato toxic mechanism of action of carbon tetra chloride and bromotrichloro methane


, : Evaluation of a role for phosgene production in the hepato toxic mechanism of action of carbon tetra chloride and bromotrichloro methane. Toxicology & Applied Pharmacology 66(2): 172-181

During aerobic incubations of rat liver microsomes containing a NADPH generating system, 1.54% of added 14CCl4 and 3.05% of added bromotrichloromethane (CBrCl3) could be recovered as the 2-oxothiazolidene-4-carboxylic acid derivative of phosgene. Actual nanomolar quantities of phosgene formed were very small in comparison to input concentrations of phosgene necessary to depress microsomal cytochrome P-450 and glucose-6-phosphatase. Cysteine had no statistically significant effect on covalent binding of 14CCl4 metabolites to either microsomal lipids or proteins. The presence of cysteine had no protective effect against loss of cytochrome P-450, glucose-6-phosphatase or the capacity of microsomes to sequester Ca2+ all of which losses occur in vitro as a result of the metabolism of either CCl4 or CBrCl3. The low level of phosgene production, the lack of any effect of cysteine on the degree of covalent binding of CCl4 metabolites, the failure of cysteine to afford any protection against CCl4- or CBrCl3-dependent loss of microsomal enzyme activity and the relative ineffectiveness of phosgene itself as a microsomal poison argue against the possibility that formation of phosgene plays a significant role in the liver injury resulting from CCl4 or CBrCl3 intoxication. These experiments, do not rule out the possibility that some phosgene production and subsequent toxicological action may occur in a hydrophobic microenvironment of the endoplasmic reticulum.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005395652

PMID: 7164096

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Shin, S.Yong.; Bajpai, V.K.; Kim, H.Ryul.; Kang, S.Chul., 2006: Antibacterial activity of bioconverted eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) against foodborne pathogenic bacteria. The antimicrobial activity of bioconversion extracts of EPA and DHA against a range of foodborne pathogenic bacteria was investigated. The bioconverted EPA and DHA exhibited antibacterial activities against four Gram-positive bacteria, Bacillus s...

Shivalli, S.; Pai, S.; Akshaya, K.Madhukeshwar.; D'Souza, N., 2016: Construction site workers' malaria knowledge and treatment-seeking pattern in a highly endemic urban area of India. Malaria Journal 15(): 168-168

Maeda; Ueda; Namioka; Ito, 1992: High-resolution measurement of Beutler-Fano profiles for autoionizing Rydberg series of Xe. Physical Review. A, Atomic, Molecular, and Optical Physics 45(1): 527-530

Troger, K.A., 1971: Inoceramus (Cordiceramus) mulled pentagonus n.ssp. aus dem Ober-Santon der subherzynen Kreidemulde. Freiberger ForschHft ; 267

Gruk, M.; Sadliński, C.; Skrzypek, J., 1968: Effect of methylthiouracil on the early course of the postoperative period in patients with nodular toxic goiter. Polski Tygodnik Lekarski 23(40): 1513-1515

Takkunen, O., 1989: Effects of heparin on serum ionized calcium and haemodynamics during coronary artery surgery. Heparin has been reported to possess hypotensive and vasodilating properties when given in 3 mg/kg bolus injection. The haemodynamic effect has been thought to be related to an acute lowering of serum ionized calcium levels. The effects of heparin...

Kuehler, C.; Lieberman, A.; Varney, A.; Unitt, P.; Sulpice, R. M.; Azua, J.; Tehevini, B., 1997: Translocation of ultramarine Lories Vini ultramarina in the Marquesas Islands: Ua Huka to Fatu Hiva. The Ultramarine Lory (Ultramarine Lorikeet, Marquesas Lorikeet, Pihiti) Vini ultramarina is one of the most threatened insular Lory species. Endemic to the Marquesas Islands, where it probably once ranged throughout the archipelago, it has been ne...

Knight W.B.; Dunaway Mariano D.; Villafranca J.J., 1982: The metal binding sites of yeast inorganic pyro phosphatase. Federation Proceedings 41(4): ABSTRACT 3732

Rubin, L.J.; Barst, R.J., 2014: Robyn J. Barst, MD. European Respiratory Journal 42(1): 16-17

Yancy, C.W., 2005: Comprehensive treatment of heart failure: state-of-the-art medical therapy. Despite advances in therapy and better outcomes for heart failure, this disease remains burdensome in terms of hospitalization costs, quality of life, and mortality. Many treatment strategies are available for heart failure, including medical ther...