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Evaluation of a saliva substitute developed for postirradiation xerostomia treatment 1. a pilot study

, : Evaluation of a saliva substitute developed for postirradiation xerostomia treatment 1. a pilot study. Chirurgia Maxillofacialis and Plastica 16(3): 123-129

A saliva substitute, with inclusion of Na-fluoride developed for the use by xerostomic patients undergoing radiotherapy for malignances of the head and neck, has been evaluated. The questionnaire was used to obtain subjective responses regarding use and effectiveness. Twenty patients have been prospectively evaluated. Xerostomia developed approximately 11 days after radiotherapy started. After treatment, all patients reported relief of intraoral soft tissue problems 1 to 15 days after the use. The condition was reported as "much better" by 30% of the patients and "better" by 70%. Duration of relief varied from 1 to 6 hours. Sixty five percent of the patients wanted to continue the use of this saliva substitute while the others had all functions of the oral cavity normalized. We recommend the use of this saliva substitute for all patients who suffer from xerostomia and suggest that longterm clinical studies should be undertaken to prove rehardening of dental tissues due to Na-fluoride inclusion.

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