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Evaluation of acrylic based modified release film coatings


, : Evaluation of acrylic based modified release film coatings. International Journal of Pharmaceutics (Kidlington) 37(3): 211-218

Although insoluble pharmaceutical additives have been generally incorporated into film-coating formulations to impart a particular color to a solid dosage form or to reduce tackiness during the coating process, the inclusion of insoluble excipients in Eudragit E 30 D formulations, instead of the commonly used hydrophilic polymers, generated predictable modified-release reserovir systems. Dissolution studies of Eudargi E 30 D-coated pellets indicated that the release profiles depended not only on the physicochemical properties of the drug, particularly solubility, but also on the coating material and hence the release rates were found to be independent of the resin in the dry film. Moreover, the integrity of the coating material and hence the release rates were found to be independent of the pH of the dissolution medium. Storing the coated pellets below the softening temperature of the Eudragit film for an extended period of time did not lead to a significant change in the release profiles. The predominant mechanism of drug release appears to be diffusion through water-filled pores in the film coat. The pellets were overcoated with a water-soluble hydrophilic polymer to prevent aggregation and enhance flowability. The overcoat did not affect the rate or extent of drug release.

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Other references

Frediani, Elisa; Tosatto, A., 1962: Cutaneous hydrating action of extracts of Rana skin. Riv Ital Essenze E Profumi 44(7): xxxi

Boswall, Jeffery., 1994: Abdims stork roosting times. Honeyguide. September; 403: 173

Cullen S.E., 1985: Molecular analysis of two mouse i region recombinants. Streilein, J Al. (ed.). Icsu (international Council Of Scientific Unions) Short Reports, Vol. 2. Advances In Gene Technology: Molecular Biology Of The Immune System; 17th Miami Winter Symposium, Miami, Fla., Usa, Feb. 11-15, . Xxiii 366p. Cambridge University Press: New York, N.y., Usa; Cambridge, England. Illus. 281-282

Suelves, A.M.; España-Gregori, E.; Aviñó, J.; Rohrweck, S.; Díaz-Llopis, M., 2013: Analysis of factors that determine the diagnostic yield of temporal artery biopsy. To analyze the diagnostic yield of temporal artery biopsy in the diagnosis of giant cell arteritis, and to correlate these results with the clinical and laboratory features which indicate it, in an attempt to increase the efficiency of this techni...

Keou, F. X-Mbopi; Gresenguet, G.; Mayaud, P.; Weiss, H. A.; Gopal, R.; Brown, Dwg; Hayes, R. J.; Mabey, Dcw; Belec, L., 1999: Genital herpes simplex virus type 2 shedding is increased in HIV-infected women in Africa. AIDS (Hagerstown) 13(4): 536-537

Messenheimer J.A.; Robertson K.R.; Wilkins J.W.; Kalkowski J.C.; Hall C.D., 1992: Event related potentials in human immunodeficiency virus infection a prospective study. P3 event-related evoked potentials (ERP) were recorded from 47 human immunodeficiency virus (HIV)-positive subjects examined twice and 29 HIV-positive subjects examined three times at 6-month intervals. The P3 latency significantly increased over...

Spradbrow, P. B., 1963: Sensitivity to drugs of Australian leptospiral serotypes. Leptospira pomona was highly susceptible to penicillin and erythromycin, susceptible to streptomycin and tetracyclines but resistant to chloramphenicol and novobiocin. In general, the twelve serotypes tested were susceptible to streptomycin, penic...

Tran My Hoang; Leplus R., 1977: Detection of the australia antigen improvement of the passive hem agglutination technique using reagents of animal origin. Revue Francaise de Transfusion et Immuno-Hematologie 20(1): 263

Rehfeldt, G., 1982: Ecological adaptations in Douglas-fir populations. II. Western Montana Pseudotsuga menziesii, genetic variation, habitat types. USDA Forest Service research paper INT United States Intermountain Forest and Range Experiment Station: 982 (295)

Currie, RI., 1986: Sir George Edward Raven Deacon, Kt., C.B.E., F.R.S., F.R.A.S., F.R.G.S., D.Sc. Royal Society of Edinburgh Year Book. 1985 ; 175-177