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Evaluation of acute and short term administration of 2 4 5 t acetate with respect to renal proximal tubular transport


, : Evaluation of acute and short term administration of 2 4 5 t acetate with respect to renal proximal tubular transport. Food and Cosmetics Toxicology 15(4): 297-302

Previous studies in rats demonstrated that a single dose (45-90 mg/kg) of 2,4,5-trichlorophenoxyacetate (2,4,5-T) reduced the transport of organic acids and bases in slices of renal cortex taken from the treated animals. Upon repeated daily administration of 2,4,5-T to rats, the daily rate of excretion of this herbicide increased after initial retention until 100% of the daily dose administered was excreted within 24 h. The ability of renal slices to transport organic ions was not facilitated during this period of increased excretion; a significant depression in transport was still measured. The high degree of binding of 2,4,5-T by renal cortical homogenates from untreated rats was not altered by pretreatment of the rats with 90 mg 2,4,5-T/kg. Single or repeated administration of the herbicide at the lower dose of 20 mg/kg did not alter the transport of organic ions significantly. From these data and others, it appears that the susceptibility of rats to the toxicity of 2,4,5-T is directly related to the ability of the animals to excrete high doses of this herbicide.

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