EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evaluation of additional absorbed radiation dose from radioactive impurities in radiopharmaceuticals


Radioisotopes 35(6): 321-324
Evaluation of additional absorbed radiation dose from radioactive impurities in radiopharmaceuticals
The additional absorbed radiation doses to total body from radioactive impurities in radiopharmaceuticals were estimated for a total of 10 samples (i.e., 99mTc generator eluates, 99mTc solutions, 67Ga, 81mKr generator eluates, 111In, 123I, 201Tl, 75Se, 197Hg, 198Au) selected from commonly used radiopharmaceuticals. The radioactive impurities in radiopharmaceuticals used in this estimation were previously identified. The radiation doses were calculated according to the MIRD procedures, assuming each radionuclide to be uniformly distributed throughout the body. In the case of the cyclotron-produced radioisotopes and 198Au, the additional total body absorbed doses from impurities were found to be rather high: 280% for 123I, 55% for 18mKr, 5% for 198Au, 4% for 111In and 2% for 201Tl. The absorbed doses due to impurities in the other radioisotopes were less than 1%.


Accession: 005395945

PMID: 3763962



Related references

Absorbed radiation dose from radionuclidic impurities in several 123I-labeled radiopharmaceuticals. Nuklearmedizin. Nuclear Medicine 15(3): 152-155, 1976

Quality control of radiopharmaceuticals (II): evaluation of radioactive impurities in radiopharmaceuticals. Kaku Igaku. Japanese Journal of Nuclear Medicine 17(6): 723-728, 1980

Comparison of radiation absorbed dose of Re-188 radiopharmaceuticals for intracoronary radiation therapy in case of balloon rupture. Journal of Nuclear Medicine 40(5 SUPPL ): 41P, May, 1999

Radiation absorbed dose to the embryo/fetus from radiopharmaceuticals. Health Physics 73(5): 756-769, 1997

Radiation absorbed dose estimates for oxygen-15 radiopharmaceuticals (H2(15)O, C15O, O15O) in newborn infants. Journal of Nuclear Medicine 29(12): 1961-1970, 1988

Comparison of the Absorbed Dose for (99m)Tc-Diethylenetriaminepentaacetic Acid and (99m)Tc-Ethylenedicysteine Radiopharmaceuticals using Medical Internal Radiation Dosimetry. Journal of Medical Signals and Sensors 5(3): 171-175, 2015

Comparison of human and animal data based radiation absorbed dose estimates for positron radiopharmaceuticals used in drug development. Journal of Nuclear Medicine 37(5 SUPPL ): 228P, 1996

Additional radiation absorbed dose estimates for ZevalinTM radioimmunotherapy. Cancer Biotherapy & Radiopharmaceuticals 18(2): 253-258, April, 2003

Additional radiation absorbed dose estimates for Zevalin radioimmunotherapy. Cancer BioTherapy & Radiopharmaceuticals 18(2): 253-258, 2003

Reduction of radioactive impurities in radiopharmaceuticals. Journal of Nuclear Medicine 13(7): 570-571, 1972