EurekaMag
+ Most Popular
Cunninghamia lanceolata plantations in China
Mammalian lairs in paleo ecological studies and palynology
Studies on technological possibilities in utilization of anhydrous milk fat for production of recombined butter-like products
Should right-sided fibroelastomas be operated upon?
Large esophageal lipoma
Apoptosis in the mammalian thymus during normal histogenesis and under various in vitro and in vivo experimental conditions
Poissons characoides nouveaux ou non signales de l'Ilha do Bananal, Bresil
Desensitizing efficacy of Colgate Sensitive Maximum Strength and Fresh Mint Sensodyne dentifrices
Administration of fluid by subcutaneous infusion: revival of a forgotten method
Tundra mosquito control - an impossible dream?
Schizophrenia for primary care providers: how to contribute to the care of a vulnerable patient population
Geochemical pattern analysis; method of describing the Southeastern limestone regional aquifer system
Incidence of low birth weights in a hospital of Mexico City
Tabanidae
Graded management intensity of grassland systems for enhancing floristic diversity
Microbiology and biochemistry of cheese and fermented milk
The ember tetra: a new pygmy characid tetra from the Rio das Mortes, Brazil, Hyphessobrycon amandae sp. n. (Pisces, Characoidei)
Risk factors of contrast-induced nephropathy in patients after coronary artery intervention
Renovation of onsite domestic wastewater in a poorly drained soil
Observations of the propagation velocity and formation mechanism of burst fractures caused by gunshot
Systolic blood pressure in a population of infants in the first year of life: the Brompton study
Haematological studies in rats fed with metanil yellow
Studies on pasteurellosis. I. A new species of Pasteurella encountered in chronic fowl cholera
Dormancy breaking and germination of Acacia salicina Lindl. seeds
therapy of lupus nephritis. a two-year prospective study

Evaluation of lipophilic properties for a series of phenols using reversed phase high performance liquid chromatography and high performance thin layer chromatography


Evaluation of lipophilic properties for a series of phenols using reversed phase high performance liquid chromatography and high performance thin layer chromatography



Journal of Chromatography 214(1): 59-68



ISSN/ISBN: 0021-9673

DOI: 10.1016/s0021-9673(00)80900-0

Experimental RM0 and log k0 values for 48 mono- to penta-substituted phenols were determined using reversed-phase high-performance liquid chromatography and high-performance TLC. Octadecylsilylated silica served as lipophilic stationary phase. RM0 and log k0 values were calculated by extrapolation of the plot of the methanol percentage composition of the mobile phase (methanol-0.01 N aqueous HCl mixtures) vs. RM or log k values to the intercept with the y-axis (i.e., 0% methanol). RM0 and log k0 values obtained under these standardized conditions are correlated significantly to the log P values reported for shake-flask partition experiments. Substituent constants derived from the chromatographic lipophilicity data, in accordance to .pi., lead to values that can be used to estimate the hydrophobic properties of other compounds.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 005399434

Download citation: RISBibTeXText

Related references

Lipophilicity measurements of protonated basic compounds by reversed phase high performance liquid chromatography 2. procedure for the determination of a lipophilic index measured by reversed phase high performance liquid chromatography. Journal of Chromatography 320(2): 305-312, 1985

Simultaneous determination of atorvastatin calcium and olmesartan medoxomil in a pharmaceutical formulation by reversed phase high-performance liquid chromatography, high-performance thin-layer chromatography, and UV spectrophotometric methods. Journal of Aoac International 97(3): 791-797, 2014

Reversed-Phase High-Performance Liquid Chromatography and High-Performance Thin-layer Liquid Chromatography Methods for Simultaneous Determination of Theophylline, Guaifenesin and Guaifenesin Impurity (Guaiacol) in Their Bulk Powders and in Dosage Form. Journal of Chromatographic Science 56(9): 846-852, 2018

Evaluation and comparison of the kinetic performance of ultra-high performance liquid chromatography and high-performance liquid chromatography columns in hydrophilic interaction and reversed-phase liquid chromatography conditions. Journal of Chromatography. a 1369: 83-91, 2014

Separation of natural polar substances by reversed phase high performance liquid chromatography centrifugal thin layer chromatography and droplet countercurrent chromatography. Journal of Chromatography 349(1): 69-76, 1985

Comparative study of peptide type antibiotics in reversed phase thin layer chromatography and reversed phase high performance liquid chromatography. Journal of Chromatography 3-96, 1984

Comparative study of peptide-type antibiotics in reversed-phase thin-layer chromatography and reversed-phase high-performance liquid chromatography. International Symposium 90 (1983) 290: 83-96, 1984

Use of ion paired reversed phase thin layer chromatography for the analysis of peptides a simple procedure for the monitoring of preparative reversed phase high performance liquid chromatography. Journal of Chromatography 236(1): 244-248, 1982

Separation of natural polar substances by reversed-phase high-performance liquid chromatography, centrifugal thin-layer chromatography and droplet counter-current chromatography. Journal of Chromatography 349(1): 69-75, 1985

Determination of furanochromones and pyranocoumarins in drugs and Ammi visnaga fruits by combined solid-phase extraction-high-performance liquid chromatography and thin-layer chromatography-high-performance liquid chromatography. Journal of Chromatography. a 797(1-2): 305-309, 1998

Separation of lepidopterous sex pheromones by reversed-phase thin layer chromatography and high performance liquid chromatography. Agricultural and biological chemistry 50(11): 2935-2937, 1986

Reversed phase high performance thin layer chromatography and column liquid chromatography of chlorophylls and their derivatives. Journal of Chromatography 408: 181-190, 1987

Ion-Pair Reversed-Phase Thin-Layer Chromatography and High-Performance Liquid Chromatography of Benzoic Acids. Journal of Analytical Chemistry 57(3): 210-214, 2002

Reversed phase high performance thin layer chromatography and column liquid chromatography of metal complexes of pheophorbide a. Journal of Chromatography 457: 99-110, 1988

Correlation between ultra-high performance liquid chromatography-tandem mass spectrometry and reversed-phase thin-layer chromatography hydrophobicity data for evaluation of angiotensin-converting enzyme inhibitors absorption. Journal of Chromatography. a 1258: 94-100, 2012