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Evaluation of measurement of serum angiotensin converting enzyme level in sarcoidosis






Japanese Journal of Thoracic Diseases 18(1): 34-39

Evaluation of measurement of serum angiotensin converting enzyme level in sarcoidosis

Serum angiotensin-converting enzyme (S-ACE) level was measured in various [human] diseases to evaluate its diagnostic value in sarcoidosis. The measurement of the enzyme activity was performed after Cushman's spectrophotometric assay, but borate buffer was used instead of phosphate buffer because the buffering action of phosphate buffer is insufficient at pH 8.3, the optimal pH of the reaction. Diseases examined were sarcoidosis (64 active and 21 inactive), pulmonary tuberculosis (25), chronic obstructive lung diseases(20), silicosis(29), liver cirrhosis(24), leprosy(50) and hyperthyroidism(21). The mean .+-. SD of the S-ACE level for 63 normal control subjects was 31 .+-. 9 U; the enzyme activity was markedly elevated in active sarcoidosis (53 .+-. 14 U). It was also elevated in liver cirrhosis (48 .+-. 11 U), silicosis (45 .+-. 10 U) and hyperthyroidism (38 .+-. 12 U). In active sarcoidosis, elevated ACE level decreased during corticosteroid therapy with improvement of chest radiological findings; this decrease also occurred in patients who had normal ACE levels before therapy. Measurement of S-ACE level apparently is a simple and useful diagnostic tool for sarcoidosis, although elevation of the S-ACE level is not specific for sarcoidosis. The decrease of the enzyme activity during corticosteroid therapy seemed to be characteristic of sarcoidosis and confirmed the diagnosis of this disease.

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Accession: 005399607



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Evaluation of measurement of serum angiotensin-converting enzyme (S-ACE) level in sarcoidosis. Nihon Kyobu Shikkan Gakkai Zasshi 18(1): 34-39, 1980

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