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Evaluation of splanchnic artery occlusion plasma for a skeletal muscle vascular dilator substance



Evaluation of splanchnic artery occlusion plasma for a skeletal muscle vascular dilator substance



Circulatory Shock 3(3): 231-238



Previous studies suggested that a skeletal muscle vascular dilation accompanies the onset of decompensatory shock induced by hemorrhagic hypotension. The objective of this study was to determine if a vasoactive substance capable of explaining this vasodilation is released from an ischemic viscera. Pancreatic venous flow and pressure, arterial pressure and lead II of the ECG were monitored from donor dogs subjected to a 2 h period of splanchnic artery occlusion (SAO). Arterial blood samples were taken 5 min before SAO, at SAO + 30 min, SAO + 60 min, SAO + 90 min and 5 min after release of the occlusion. The plasma from these samples was frozen for subsequent evaluation in a 2nd group of recipient dogs in which skeletal muscle blood flow, arterial blood pressure and lead II of the ECG were monitored during intra-arterial injection of 1.0 ml of the SAO plasma into the skeletal muscle vascular bed of animals with both normal vascular tone and high vascular tone induced by hemorrhage. None of the plasma samples obtained from the SAO dogs contained enough vasoactive material to explain the vascular decompensation observed in the previous study.

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Accession: 005401871

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