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Evaluation of steroid tests in liver diseases especially serum transaminase activity

Evaluation of steroid tests in liver diseases especially serum transaminase activity

Tokyo Jikeikai Medical Journal 99(3): 521-534

In 13 patients with chronic hepatitis, the rebound phenomenon of serum transaminase was observed after corticosteroid medication. In some, the phenomenon was prominent at the 1st stage of medication, while in others gradual increase was observed. Rapid steroid test were carried out in patients with various hepatic diseases to examine effects on serum transaminase activity. Rapid i.v. administration of steroid (hydrocortisone succinate, 25 mg) was given to healthy volunteers, patients with acute hepatitis, chronic hepatitis and liver cirrhosis, who then were all diagnosed by needle biopsy. Measurements of serum transaminase activities were carried out before and at 30, 60, 120 and 240 min after the steroid loading. Animal experiments on choline-deficient rats showed that the effects of the steroid hormone on the liver and the serum transaminase activities varied in different stages after choline-deficient diet per os. In the active stage of severe inflammation of chronic liver damage, elevation of serum transaminase activities induced by the given steroid was different from that elicited by the injury mechanism. This finding had important practical implication in the use of corticosteroids for patients with chronic liver diseases as the sign of its active stage.

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Accession: 005401936

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