+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma

, : Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma. Lancet 1(8278): 935-937

The 2-component hypothesis of acute inflammation postulates that the acute inflammatory response depends on increased local blood flow and increased microvascular permeability; the validity of this concept, previously established in animals, was tested in man. A mixture of the mediators prostaglandin E2 and bradykinin produces a larger cutaneous wheal (volume) response than can be accounted for by summation of the responses to the individual substances or by the slopes of their dose-response curves. This enhanced response is inhibited by noradrenaline [norepinephrine] (consistent with the vasoconstrictor property of noradrenaline) and by salbutamol (consistent with the antipermeability property of salbutamol). The 2-component hypothesis of acute inflammation may apply to man as well as animals; this finding is important in the evaluation of the role of putative mediators in the pathogenesis of asthma and other diseases in which inflammation plays a part.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005411011

PMID: 6122773

DOI: 10.1016/S0140-6736(82)91935-3

Download PDF Full Text: Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

He, Y-Ying.; Chignell, C.F.; Miller, D.S.; Andley, U.P.; Roberts, J.E., 2004: Phototoxicity in human lens epithelial cells promoted by St. John's Wort. St. John's Wort (SJW), an over-the-counter antidepressant, contains hypericin, which absorbs light in the UV and visible ranges and is phototoxic to skin. To determine if it also could be phototoxic to the eye, we exposed human lens epithelia...

Hofer, S.; Plachky, J.; Fantl, R.; Schmidt, J.; Bardenheuer, H.J.; Weigand, M.A., 2006: Postoperative pulmonary complications: prophylaxis after noncardiac surgery. Postoperative pulmonary complications are a major problem after upper abdominal or thoracoabdominal surgery. They lead to a prolonged ICU stay as well as increased costs and are one of the main causes of early postoperative mortality. Even after u...

Davies, E.L.; Shennan, K.I.J.; Docherty, K.; Bailey, C.J., 1996: Glucose-sensitive insulin-secreting AtT20 cells A model for insulin delivery by somatic cell gene therapy. Diabetologia 39(SUPPL 1): A137

Hofelmeier, G., 1991: Effect of lasalocid on transport properties of isolated forestomach epithelia of sheep. This thesis concludes that high doses of lasalocid elicit unspecific and negative effects on transport properties of the rumen and omasum epithelium in vitro and in vivo. Active and passive transport pathways are influenced. The mechanism(s) of th...

Aoki, T.; Nakamuta, Y.; Toh, S.; Nakamura, T., 2008: TEM observations of synthesized forsterite crystals after shock experiments. Meteoritics & Planetary Science 43, .

Tandon, R. S., 1949: A new trematode, Lissemysia ovata n.sp. of the family Aspidogastridae Poche, 1907 from fresh water molluscs. Lissemysia ovata n.sp. in Vivipara bengalensis, Lamellidens corrianos and Indonaia caerulea from the Kukrail stream near Lucknow is described and figured, and is differentiated from L. indica. The diagnosis of Lissemysia is emended.

Garner, J., 1974: Penalties for possession lighter under new law on cannabis. Canadian Medical Association Journal 111(11): 1283-1283

Nunez-Ricardo, S.; Marchant, M.; Hayward, B.; Hebbeln, D., 2007: Mid-Pleistocene Stilostomella extinction event off northern Chile (25 degrees S). Based on sediment samples from core site GeoB 3388-1 from the Iquique Ridge off northern Chile (25 degrees S), we report the last appearance datum (LAD) of seven species that belong to the Stilostomella extinction group. The Stilostomella extincti...

Schmidt, G.; Majoros, M., 1963: Hardseededness of lucerne and clovers, and possibilities of overcoming it.. The average percentages of hard seeds in lucerne, red clover, white clover and birdsfoot trefoil were 19.5, 7.5, 19-22 and 4.5, respectively. Hardseededness could be overcome by soaking the seeds in 8% gypsum solution. 3 days after soaking 45-52%...

Garro, S.; Bava, A.J., 2007: Cryptococcus neoformans in the gastric contents of an AIDS patient. The microscopic observation and isolation of Cryptococcus neoformans from the gastric contents of an AIDS patient, obtained by aspiration with a nasogastric catheter and parasitologically studied, is communicated. Because of the limited number of...