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Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma

Lancet 1(8278): 935-937
Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma
The 2-component hypothesis of acute inflammation postulates that the acute inflammatory response depends on increased local blood flow and increased microvascular permeability; the validity of this concept, previously established in animals, was tested in man. A mixture of the mediators prostaglandin E2 and bradykinin produces a larger cutaneous wheal (volume) response than can be accounted for by summation of the responses to the individual substances or by the slopes of their dose-response curves. This enhanced response is inhibited by noradrenaline [norepinephrine] (consistent with the vasoconstrictor property of noradrenaline) and by salbutamol (consistent with the antipermeability property of salbutamol). The 2-component hypothesis of acute inflammation may apply to man as well as animals; this finding is important in the evaluation of the role of putative mediators in the pathogenesis of asthma and other diseases in which inflammation plays a part.

Accession: 005411011

PMID: 6122773

DOI: 10.1016/S0140-6736(82)91935-3

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