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Evidence in vivo for a circulating natriuretic substance in rats after expanding the blood volume

Clinical Science 59(6): 411-421
Evidence in vivo for a circulating natriuretic substance in rats after expanding the blood volume
Five rats were volume expanded by infusing a volume of blood equivalent to 1/3 of the estimated blood volume. In 6 control experiments the same transfusion was given without expanding the blood volume, as an equal volume of blood was simultaneously removed. Na excretion increased significantly more after the blood volume was expanded than in the control experiments. Pairs of rats placed on opposite scale pans of a trip balance were cross-circulated by arteriovenous bypasses. The blood volume of the rats could be kept constant by keeping the balance in equilibrium. One of each pair of rats received a blood transfusion which either did or did not expand its blood volume. Na excretion was measured in the transfused rat and in the recipient rat, the blood volume of which was kept constant. Na excretion in the 6 recipient rats cross-circulated with rats with an expanded blood volume was not significantly different from that in 6 recipient rats, cross-circulated with rats given a transfusion which did not expand the blood volume. The cross-circulation experiments were repeated, with the difference that the urine of the transfused rat was reinfused. Under these conditions, Na excretion in 11 recipient rats cross-circulated with blood volume expanded rats was significantly greater than in 8 recipient rats cross-circulated with rats given a transfusion which did not expand the blood volume. In cross-circulation experiments in which a blood transfusion was not given urine reinfusion of 1 rat did not affect Na excretion of the other rat. The rise in urinary Na excretion which occurs in an isovolemic recipient rat cross-circulated with a urine reinfused rat with an expanded blood volume apparently is due to a change in the concentration of a circulating substance.

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Accession: 005411026

PMID: 7192198

DOI: 10.1042/cs0590411

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