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Evidence indicating independent assortment of framework and complementarity determining segments of the variable regions of rabbit light chains


, : Evidence indicating independent assortment of framework and complementarity determining segments of the variable regions of rabbit light chains. Journal of Experimental Medicine 152(1): 72-84

Amino acid sequences of rabbit L chains show considerable evidence of independent assortment of framework (FR) and complementarity-determining (CDR) segments. Apparently, they are coded for by independent genetic units (minigenes) and individual L chanins are assembled somatically by recombining these units. Identical FR sets with multiple members generally comprise chains with different specificities; identical CDR sets tend to have chains of a single specificity. A J segment, which, by analogy with mouse L chains, is made up of the last 2 residues of CDR3 plus all of FR4, contained 18 different sets and could contribute to diversity generated by CDR3. The longest segment, FR3, had a very large number of sets. The number of sets could be substantially reduced by permitting FR3 to be formed by 2 independently assorting segments comprising residues 57-68 and 69-88.

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