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Evidence of a pure contraction alkalosis in the conscious rat


, : Evidence of a pure contraction alkalosis in the conscious rat. Biomedicine Express (Paris) 25(5): 161-162

A pure contraction alkalosis with no urinary loss of bicarbonate was evidenced in the conscious rat, after a Furosemide IV injection. An early and important respiratory compensation occurred, possibly owing to a simultaneous contraction of CSF [cerebrospinal fluid] volume, increasing bicarbonate concentration. A net shift of HCO3- towards intracellular compartment was observed, in proportion to the magnitude of the contraction rather than to bicarbonate gradient across the membrane.

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