EurekaMag.com logo
+ Translate

Evidence of a role for gamma amino butyric acid in benzodiazepine effects on food preference in rats


, : Evidence of a role for gamma amino butyric acid in benzodiazepine effects on food preference in rats. Psychopharmacology 75(3): 305-310

Chronic treatment with the GABA-transaminase inhibitor ethanolamine-O-sulfate (EOS), which elevates brain GABA levels by .apprx. 200%, selectivity enhances novel food consumption in rats treated with chlordiazepoxide (CDP) and given a food preference test. To replicate and extend these findings, the effects of 2 doses of CDP with and without EOS pretreatment were compared with those of EOS or saline alone. EOS alone had no significant effects except to decrease eating rate but, in combination with 2.5 mg/kg CDP, it antagonized the increase in weight of familiar food eaten found with CDP alone and marginally increased weight eaten and duration of novel food-eating episodes. EOS magnified the effects of 5.0 mg/kg CDP to increase markedly the weight eaten and duration of episodes for novel chocolate drops. As no additive effects of EOS and CDP on rate of eating were found, the results are consistent with a facilitation of novel food consumption by an anxiolytic action of the 2 drugs, rather than by a rate-retarding action which might bias animals toward novel food. That EOS alone did not mimic the effects of CDP suggests that the role of GABA in the anxiolytic action of CDP may be indirect.

(PDF 0-2 workdays service)

Accession: 005411150

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Schechter, P.J.; Tranier, Y.; Jung, M.J.; Bohlen, P., 1977: Audiogenic seizure protection by elevated brain gamma amino butyric acid concentration in mice effects of gamma acetylenic gamma amino butyric acid and gamma vinyl gamma amino butyric acid 2 irreversible gamma amino butyric acid trans aminase inhibitors. .gamma.-Acetylenic GABA and .gamma.-vinyl GABA, 2 catalytic irreversible inhibitors of GABA-transaminase, produce marked and sustained elevations in mouse brain GABA concentrations and protect DBA/2 mice against audiogenically induced seizures in...

Guidotti A.; Corda M.G.; Vaccarino F.M.; Wise B.C., 1984: Role of gamma amino butyric acid modulin and of an endogenous effector of beta carboline binding sites in the gamma amino butyric acid benzodiazepine receptor interaction. Bowery, N G Actions And Interactions Of Gaba And Benzodiazepines: A Biological Council Symposium; London, England, Mar 21-22, 1983 Xiii+298p Raven Press: New York, N Y , Usa Illus P191-202

Bousquet P.; Feldman J.; Bloch R.; Schwartz J., 1982: Evidence for a neuro modulatory role of gamma amino butyric acid at the 1st synapse of the baro receptor reflex pathway effects of gamma amino butyric acid derivatives injected into the nucleus tractus solitarii. Microinjections of GABA and of the specific agonist of GABA receptors, muscimol, in the intermediate nucleus tractus solitarii (NTS) of pentobarbitone-anesthetized cats produced hypertension and tachycarida. The GABA receptor antagonist, bicuculli...

Burch T.P.; Thyagarajan R.; Ticku M.K., 1983: Group selective reagent modification of the benzodiazepine gamma amino butyric acid receptor ionophore complex reveals that low affinity gamma amino butyric acid receptors stimulate benzodiazepine binding. The modification of membrane proteins with diethylpyrocarbonate (DEP) and diazotized sulfanilate was investigated on the binding of 3 benzodiazepine radioligands in 3 [rat] brain regions. Both of these reagents produced a dose-dependent inactivati...

Squires R.F., 1979: Evidence for gamma amino butyric acid associated and gamma amino butyric acid independent benzodiazepine receptor complexes in brain. Brain Research Bulletin: 701

Smokcum R.W.J., 1983: Inactivation of gamma amino butyric acid receptors by phenoxybenzamine effects on gamma amino butyric acid stimulated benzodiazepine binding in the central nervous system. Treatment of particulate fractions of rat forebrain with phenoxybenzamine produced dose-related inhibition of specific muscimol binding. Scatchard analysis revealed a significant reduction of binding sites but no change in affinity constant. The i...

Corradetti R.; Moroni F.; Pepeu G., 1980: Pharmacological effects of benzodiazepines in the leech hirudo medicinalis benzodiazepine and gamma amino butyric acid receptors and gamma amino butyric acid level. Benzodiazepines exerted clear pharmacological effects on leech spontaneous behavior. In the leech ganglia no benzodiazepine receptors were found. A specific high affinity GABA [.gamma.-aminobutyric acid] binding was detected and the concentrations...

Van Der Laan J.W.; Jacobs A.W.C.M.; Bruinvels J., 1980: Effects of branched chain fatty acids on gamma amino butyric acid degradation and behavior further evidence for a role of gamma amino butyric acid in quasi morphine abstinence behavior. An increase in GABA-ergic activity was implicated in the initiation of quasi-morphine abstinence behavior by di-n-propylacetate (DPA) in the rat. Two structural analogs of DPA, namely, the branched-chain-fatty acid 2-methyl, 2-ethylcaproic acid an...

Jung, M.J.; Lippert, B.; Metcalf, B.W.; Bohlen, P.; Schechter, P.J., 1977: Gamma vinyl gamma amino butyric acid 4 amino hex 5 enoic acid a new selective irreversible inhibitor of gamma amino butyric acid trans aminase effects on brain gamma amino butyric acid metabolism in mice. .gamma.-Vinyl GABA (4-amino-hex-5-enoic acid, RMI 71754) is a catalytic inhibitor of GABA-T in vitro. When given by a peripheral route to mice, it crossed the blood-brain barrier and induced a long-lasting, dose-dependent, irreversible inhibition...

Nistico G.; D.G.orgio R.M.; D.L.ca G.; Macaione S., 1979: Effects of ethanolamine o sulfate and gamma acetylenic gamma amino butyric acid on gamma amino butyric acid content and gamma amino butyric acid trans aminase in various areas of chick brain after intra ventricular micro injection. Journal of Neurochemistry 33(1): 343-346