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Evidence of a thromboxane a 2 calcium complex a conformational approach


, : Evidence of a thromboxane a 2 calcium complex a conformational approach. Research Communications in Chemical Pathology & Pharmacology 46(2): 175-186

Thromboxane A2 has been proposed as an ionophore capable to transport Ca from the platelet dense tubular system to the cytoplasm to activate the contractile proteins. However, the half-life (30 s) of this compound limits considerably the experimental approach. The conformational analysis is proposed here as a possible way to identify such transient conformations. There is evidence of the existence of 2 Ca2+-thromboxane A2 isomeric complexes: one structure responsible for the complexation-decomplexation process at the interface and one lipophilic structure able to cross the lipid membrane.

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