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Evidence of altered calcium accumulation and calcium binding by the membranes of adipocytes in spontaneously hypertensive rats


, : Evidence of altered calcium accumulation and calcium binding by the membranes of adipocytes in spontaneously hypertensive rats. Pfluegers Archiv European Journal of Physiology 385(1): 85-90

Ca accumulation and Ca binding (ATP-dependent and ATP-independent Ca uptake) by the fragmented plasma membrane, the cytoplasmic reticulum and the mitochondria of isolated adipocytes obtained from spontaneously hypertensive (SHR, Kyoto-Wistar) and normotensive Wistar and Kyoto-Wistar rats were studied by means of isotopic (45Ca) exchange in vitro. The value of Ca accumulation in the cytoplasmic reticulum fraction of adipocytes obtained from SHR was decreased, while in the mitochondrial fraction it was considerably greater compared to those in both normotensive control groups. Ca binding (ATP-independent) by the plasma membrane fraction of hypertensive rats was less than that of the normotensive rats. There was no difference between the groups studied in Ca binding ability for the cytoplasmic reticulum fraction of adipocytes. The adipose cells of hypertensive rats evidently have an alteration of the membrane mechanism maintaining intracellular Ca distribution.

Accession: 005411208

PMID: 7191099

DOI: 10.1007/bf00583919

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