EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence of altered calcium accumulation and calcium binding by the membranes of adipocytes in spontaneously hypertensive rats


Pfluegers Archiv European Journal of Physiology 385(1): 85-90
Evidence of altered calcium accumulation and calcium binding by the membranes of adipocytes in spontaneously hypertensive rats
Ca accumulation and Ca binding (ATP-dependent and ATP-independent Ca uptake) by the fragmented plasma membrane, the cytoplasmic reticulum and the mitochondria of isolated adipocytes obtained from spontaneously hypertensive (SHR, Kyoto-Wistar) and normotensive Wistar and Kyoto-Wistar rats were studied by means of isotopic (45Ca) exchange in vitro. The value of Ca accumulation in the cytoplasmic reticulum fraction of adipocytes obtained from SHR was decreased, while in the mitochondrial fraction it was considerably greater compared to those in both normotensive control groups. Ca binding (ATP-independent) by the plasma membrane fraction of hypertensive rats was less than that of the normotensive rats. There was no difference between the groups studied in Ca binding ability for the cytoplasmic reticulum fraction of adipocytes. The adipose cells of hypertensive rats evidently have an alteration of the membrane mechanism maintaining intracellular Ca distribution.

Accession: 005411208

PMID: 7191099

DOI: 10.1007/bf00583919

Download PDF Full Text: Evidence of altered calcium accumulation and calcium binding by the membranes of adipocytes in spontaneously hypertensive rats



Related references

Calcium accumulation and calcium binding by the cell membranes of cardiomyocytes and smooth muscle of aorta in spontaneously hypertensive rats. Clinical Science 59 Suppl 6: 207s-209s, 1980

Altered calcium domains which regulate dihydropyridine binding to calcium channel in spontaneously hypertensive rats. Circulation 80(4 SUPPL 2): II22, 1989

Altered active sodium and calcium transport by heart sarcolemmal membranes from young spontaneously hypertensive rats: modulation by calmodulin. Journal of Hypertension. Supplement 2(3): S485-S487, 1984

Altered calcium dependent calcium release from intracellular sites of perfused heart in spontaneously hypertensive rats. Sassard, J (Ed ) Colloques Inserm (Institut National De La Sante Et De La Recherche Medical), Vol 218 Hypertension Genetique; (Inserm (National Institute Of Health And Medical Research) Colloquium, Vol 218 Genetic Hypertension); Seventh International Symposium on Shr (Spontaneously Hypertensive Rats) And Related Studies, Lyon, France, October 28-30, 1991 Xxii+618p Editions John Libbey Eurotext: Montrouge, France; London, England, Uk; Editions Inserm: Paris, France Illus Paper 56, 1992

Exaggerated rate of tubular calcium transport in the pre hypertensive stage of spontaneously hypertensive rats further evidence for a generalized defect in membrane calcium regulation. Clinical Research 33(2 PART 1): 490A, 1985

Calmodulin abolishes the changes in calcium ii binding and transport by heart sarcolemmal membranes of spontaneously hypertensive rats. Life Sciences 36(25): 2367-2374, 1985

Atp dependent calcium transport and sodium calcium exchange system in renal basolateral plasma membranes of spontaneously hypertensive rats. Clinical & Experimental Hypertension Part A Theory & Practice 7(12): 1719-1732, 1985

Reduced calcium sensitivity of dihydropyridine binding to calcium channels in spontaneously hypertensive rats. Hypertension 17(2): 234-241, 1991

Calcium fluxes calcium binding and cyclic amp dependent protein kinase activity in the aorta of spontaneously hypertensive and kyoto wistar normotensive rats. Molecular Pharmacology 14(3): 468-477, 1978

Effects of dietary calcium deprivation on calcium absorption and serum 1 25 dihydroxyvitamin d 3 levels in young spontaneously hypertensive rats shr evidence for deranged regulation of vitamin d metabolism. Clinical Research 34(2): 541A, 1986