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Evidence of cardiac autonomic disease in chronic alcoholics by computerized study of heart rate respiration relationship

, : Evidence of cardiac autonomic disease in chronic alcoholics by computerized study of heart rate respiration relationship. Cardiologia (Rome) 31(9): 721-724

We have performed heart rate variation autonomic tests, associated with the respiration, in a group of 16 patients with chronic alcoholism and without clinical findings of autonomic damage and in 14 normal age-matched subjects, in order to detect possible occurrence of early autonomic damage. Heart rate, RR range (RG), RR standard deviation (SD), mean successive difference (MSD), mean squared successive difference (MSSD) and cross-correlation between heart rate and respiration were evaluated. Most of the autonomic function tests performed showed statistically significant differences between the 2 groups: cross-correlation values showed the largest difference (p < 0.01) between alcoholic and normal subjects; followed by MSD (p < 0.02), MSSD and SD (p < 0.05), RG (p:ns). Cross-correlation method had the highest amount of abnormal findings: 11 out of 16 alcoholic subjects were below 2 standard deviations from control group distribution. These results suggest early autonomic disease is a rather common feature of chronic alcoholic subjects. The association between heart and respiration (as assessed by the cross-correlation method) provided the best discrimination between the 2 groups and appeared the most sensitive method for detection of early autonomic damage.

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Accession: 005411281

PMID: 3545471

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