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Evidence of cellular sensitization in allergic alveolitis caused by avian protein


, : Evidence of cellular sensitization in allergic alveolitis caused by avian protein. Deutsche Gesundheitswesen 37(34): 1489-1493

In professional chicken breeders (n = 50) and in pigeon-breeders some of whom were healthy and some of whom suffered from allergic alveolitis (n = 25), the cell-mediated immuno-reactivity was tested by lymphocyte transformation. The result of specific lymphocyte stimulation was correlated with further parameters (detection of precipitating antibodies, PHA[phytohemagglutinin]-lymphocyte stimulation, respiratory physiological parameters, lenght of exposition, appearance of clinical symptoms when exposed). Cellular sensitization apparently does not play the decisive pathogenic role in the development of an allergic alveolitis so that the diagnostic value of a detectable cellular reaction in vitro remains limited. The detection of antigen-specific cellular sensitization and the detection of precipitating antibodies can be regarded as being of equal value as indicators of past sensitization.

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