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Evidence of cyclic alterations of thyroid size during the menstrual cycle in healthy women

American Journal of Obstetrics & Gynecology 155(1): 142-145

Evidence of cyclic alterations of thyroid size during the menstrual cycle in healthy women

Serum levels of thyroxine, triiodothyronine, triiodothyronine resin uptake, thyroxine-binding globulin, thyrotropin, and ultrasonically determined thyroid gland volume were investigated weekly in 11 healthy women during a normal menstrual cycle, and in five healthy men once a week for 5 consecutive weeks. In the men the thyroid volume was unaltered. In the women, however, a mean variation in thyroid volume of approximately 50% between minimum values (15.4 .+-. 3.1 ml, day 9) and maximum values (24.4 .+-. 4.8 ml, day 23) was found (p < 0.01), although no significant differences in the other thyroid variables could be demonstrated. The menstrual cycle seems to be associated with cyclic alterations of thyroid size in healthy women unexplained by alterations in thyroid function variables. This formation should be taken into account when goiter frequency, goitrogenic action of drugs, and goiter treatment effects are evaluated.

Accession: 005411326

PMID: 3524236

DOI: 10.1016/0002-9378(86)90098-0

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