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Evidence of decreased plasma substance p levels in human essential hypertension influence of prazosin treatment


, : Evidence of decreased plasma substance p levels in human essential hypertension influence of prazosin treatment. Biomedica Biochimica Acta 42(7-8): 1019-1026

Patients with essential hypertension (n = 45) had significantly lower substance P plasma levels (13.6 .+-. 2.30 pg/ml) in comparison with a group of 24 normotensive subjects (45.4 .+-. 7.18 pg/ml) analyzed by radioimmunoassay. Prazosin treatment for 2 wk with 4.5 mg/day enhanced the substance P plasma level depending on its antihypertensive effect. Norepinephrine concentration in plasma was also elevated by prazosin. Dipeptidylpeptidase IV, dopamine-.beta.-hydroxylase and plasma renin activity were not changed significantly. Evidently, substance P participates in pathophysiological processes of human essential hypertension.

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