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Evidence of digoxin metabolism by the kidney


, : Evidence of digoxin metabolism by the kidney. Canadian Journal of Physiology & Pharmacology 65(12): 2500-2503

By performing single pass experiments in the dog, we could identify by thin layer chromatography a digoxin metabolite produced by the kidney. In vitro studies verify that this new species is produced by the brush border membrane of the renal tubular cell.

Accession: 005411356

PMID: 3449207

DOI: 10.1139/y87-398

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Related references

Bergmann K.V.; Abshagen U.; Rietbrock N., 1971: Metabolism of digoxin acetyl digoxin and methyl digoxin in the rat. Naunyn-Schmiedebergs Archiv fuer Pharmakologie 270(SUPPL):

Larbig, D.; Haasis, R.; Bundschu, H.D.; Buckesfeld, R.G.; Lankisch, P.G.; Ilg, R.; Girndt, J., 1974: Radioimmunochemical analysis of digoxin and digoxin derivatives in the serum and urine during normal and impaired kidney function. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 80: 1077-1080

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Doherty, J.E.; Perkins, W.H., 1966: Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease. Annals of Internal Medicine 64(3): 489-507

D.L.nnoy, I.A.; Koren, G.; Klein, J.; Charuk, J.; Silverman, M., 1992: Cyclosporin and quinidine inhibition of renal digoxin excretion: evidence for luminal secretion of digoxin. We studied the in vivo luminal and contraluminal uptake of (3H)digoxin in dog kidney using the single-pass multiple indicator dilution method. A bolus tracer of 125I-albumin (plasma reference), creatinine, or L-(14C)glucose (extracellular referenc...

Zilly, W.; Richter, E.; Rietbrock, N., 1975: Pharmacokinetics and metabolism of digoxin- and beta-methyl-digoxin-12aplha-3 H in patients with acute hepatitis. Pharmocokinetics and metabolism of digoxin and beta-methyldigoxin have been studied in patients with acute hepatits after intravenous administration of both H-labeled glycosides. In contrast to digoxin, the rate of decline of radioactivity after a...

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