+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence of digoxin metabolism by the kidney

Canadian Journal of Physiology & Pharmacology 65(12): 2500-2503

Evidence of digoxin metabolism by the kidney

By performing single pass experiments in the dog, we could identify by thin layer chromatography a digoxin metabolite produced by the kidney. In vitro studies verify that this new species is produced by the brush border membrane of the renal tubular cell.

Accession: 005411356

PMID: 3449207

DOI: 10.1139/y87-398

Download PDF Full Text: Evidence of digoxin metabolism by the kidney

Related references

Metabolism of digoxin acetyl digoxin and methyl digoxin in the rat. Naunyn-Schmiedebergs Archiv fuer Pharmakologie 270(SUPPL):, 1971

Radioimmunochemical analysis of digoxin and digoxin derivatives in the serum and urine during normal and impaired kidney function. Verhandlungen der Deutschen Gesellschaft für Innere Medizin 80: 1077-1080, 1974

Characteristics of the digoxin-quinidine and digoxin-verapamil interactions in the rat kidney. Research Communications in Chemical Pathology and Pharmacology 45(1): 3-18, 1984

Digoxin metabolism in hypo- and hyperthyroidism. Studies with tritiated digoxin in thyroid disease. Annals of Internal Medicine 64(3): 489-507, 1966

Cyclosporin and quinidine inhibition of renal digoxin excretion: evidence for luminal secretion of digoxin. American Journal of Physiology 263(4 Pt 2): F613-F622, 1992

Pharmacokinetics and metabolism of digoxin- and beta-methyl-digoxin-12aplha-3 H in patients with acute hepatitis. Clinical Pharmacology and Therapeutics 17(3): 302-309, 1975

Digoxin toxicity secondary to inhibition of digoxin intestinal metabolism in a patient receiving clarithromycin. Medicina Clinica 123(16): 639-639, 2004

Metabolism of digoxin: role of the liver in tritiated digoxin degradation. Journal of Pharmacology and Experimental Therapeutics 150(3): 463-468, 1965

Renal function, digoxin therapy, and heart failure outcomes: evidence from the digoxin intervention group trial. Journal of the American Society of Nephrology 15(8): 2195-2203, 2004

Metabolism of digoxin in man high dosage associated with increased reduction of the double bond in the 17 beta lactone ring of digoxin. Federation Proceedings 36(3): 938, 1977