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Evidence of direct thyroid stimulating action of trh by perifusion of rat thyroid fragments






Endocrinology 116(2): 561-566

Evidence of direct thyroid stimulating action of trh by perifusion of rat thyroid fragments

TRH stimulation with rat thyroid fragment perfusion was tested. Significant T4 [thyroxine] release was observed for TRH concentrations as low as 1.7 .times. 10-11 M. A dose-response curve was determined. The response was immediate, reaching a peak after the 6th min and continuing for 15 min after the stimulation had ceased. This kinetic pattern is different from the one observed with TSH and with theophylline and suggests that a different mechanism may be involved. TRH seems to be capable of directly stimulating both the secretion of the pituitary hormone (TSH) and the corresponding peripheral gland, like LHRH, which also acts directly on the Leydig cells of the testis.

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Accession: 005411359



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