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Evidence of diurnal variation of human epidermal cell proliferation 2. duration of epidermal dna synthesis


Archives of Dermatological Research 271(1): 49-54
Evidence of diurnal variation of human epidermal cell proliferation 2. duration of epidermal dna synthesis
In the epidermis of 6 healthy male volunteers DNA synthesis time was measured by an in vitro double labeling technique in a longitudinal study (48 h) taking skin punch biopsies every 6 h. The external conditions of the experiments and 1 group of volunteers were identical to those of a previous study on LI [labeling index] of the epidermal keratinocytes. 14C-thymidine and 3H-thymidine were used for double labeling the DNA-synthesizing nuclei of keratinocytes. The duration of DNA replication time proved nearly constant, with minor fluctuation, during the entire time span of experiments (mean 6.19 .+-. 0.3 h). Results are in accordance with the idea that a periodically changing entrance rate of G1-cells into the S-phase of the generation cycle of keratinocytes is predominantly responsible for circadian variations in the number of DNA-synthesizing epidermal keratinocytes.


Accession: 005411363

PMID: 7197509



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