+ Translate

Evidence of hybrid cell of thyroid follicular cell and carcinoid cell in strumal carcinoid

, : Evidence of hybrid cell of thyroid follicular cell and carcinoid cell in strumal carcinoid. International Journal of Gynecological Pathology 5(3): 269-277

A strumal carcinoid associated with mature cystic teratoma of the ovary in a 59-year-old was investigated immunohistochemically and electron microscopically. Histologically it was composed largely of trabecular and partly of insular carcinoid and individual thyroid follicles. Intensive argyrophilia was shown in both the cells of carcinoid tumor and follicular structure. Thyroglobulin was strongly positive in the follicular lining epithelium and weakly positive in the carcinoid cells adjacent to the follicular area. Immunoreactive cells for somatostatin and prostatic acid phosphatase were strongly detected in the carcinoid area and gradually blended to the follicular epithelium. Methionine-enkephalin, glicentin, and pancreatic polypeptide were focally detected in the carcinoid area. Whereas calcitonin-positive cells were sparsely observed in the follicular area, carcinoembryonic antigen and serotonin were absolutely negative. Electron microscopic findings revealed abundant neurosecretory granules, microfilaments, and colloid-like droplets in the same cells. We suggest that these hybrid cells are the origin of strumal carcinoid.

(PDF same-day service: $19.90)

Accession: 005411476

PMID: 3759324

DOI: 10.1097/00004347-198609000-00009

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Robboy S.J.; Scully R.E., 1980: Strumal carcinoid of the ovary an analysis of 50 cases of a distinctive tumor composed of thyroid tissue and carcinoid. Strumal carcinoid of the ovary is a type of germ-cell tumor characterized by an intimate mixture of thyroid tissue and carcinoid. Fifty patients with this type of tumor ranged in age from 21-77 yr. The tumors measured up to 26 cm in diameter and w...

Capelozzi, V.L.; Dewar, A.; Rogers, A.; Aben, V.; Saldiva, P.H.N.; Sheppard, M., 1994: Morphometric characterization of typical carcinoid , atypical carcinoid , large cell neuroendocrine carcinoma and small cell carcinoma of the lung based on ultrastructural and stereological procedure. Chest 106(2 SUPPL ): 90S

Khor, T.Sheng.; Shen, J.; Lauwers, G.Y.; Deshpande, V., 2011: Comment on the article by Chetty et al on combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. (Am J Surg Pathol 34(8): 1163-1167). American Journal of Surgical Pathology 35(8): 1248-1250

Nicolescu, P.G.; Taşcă, C.; Sajin, M., 1990: Histopathologic aspects in a case of strumal carcinoid (struma ovarii and carcinoid). The authors present the histopathologic aspects in a case of strumal carcinoid (struma ovarii and carcinoid) with 5 years clinical follow-up. The differential diagnosis difficulties between a thyroid carcinoma developed within a struma ovarii and...

Brunaud, L.; Antunes, L.; Sebbag, H.; Bresler, L.; Villemot, J.P.; Boissel, P., 2001: Ovarian strumal carcinoid tumor responsible for carcinoid heart disease. We report a case of right ovarian strumal carcinoid tumor responsible for tricuspid regurgitation. Valve replacement and salpingo-oophorectomy were performed. Serotonin level and tomodensitometry were normal at 3-year follow-up. Rarity of strumal...

Chetty, R.; Klimstra, D.S.; Henson, D.E.; Albores-Saavedra, J., 2010: Combined classical carcinoid and goblet cell carcinoid tumor: a new morphologic variant of carcinoid tumor of the appendix. Carcinoid tumors are the most common neoplasms of the appendix. Histologically they have been categorized as classical, tubular, or goblet cell types. Goblet cell carcinoid has been regarded as a distinctive tumor type, not related to classic carc...

Gonzalez-Licea, A.; Hartmann, W.H.; Yardley, J.H., 1968: Medullary carcinoma of the thyroid. Ultrastructural evidence of its origin from the parafollicular cell and its possible relation to carcinoid tumors. American Journal of Clinical Pathology 49(4): 512-520

Taggart, M.W.; Abraham, S.C.; Overman, M.J.; Mansfield, P.F.; Rashid, A., 2015: Goblet cell carcinoid tumor, mixed goblet cell carcinoid-adenocarcinoma, and adenocarcinoma of the appendix: comparison of clinicopathologic features and prognosis. The prognosis of appendiceal goblet cell carcinoid tumors (GCTs) is believed to be intermediate between appendiceal adenocarcinomas and conventional carcinoid tumors. However, GCTs can have mixed morphologic patterns, with variable amount of adeno...

Evers, B.M.; Ishizuka, J.; Townsend, C.M.; Thompson, J.C., 1994: The human carcinoid cell line, BON. A model system for the study of carcinoid tumors. Annals of the New York Academy of Sciences 733: 393-406

Greene, J.F.; Doyle, W.F., 1974: Pancreatic islet cell carcinoid: a highly malignant form of carcinoid tumor. Journal of Surgical Oncology 6(3): 183-190