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Evidence of increased intestinal synthesis and extracellular deposition of immuno globulin m in primary biliary cirrhosis an immuno fluorescence study of liver and small intestinal biopsy specimens


, : Evidence of increased intestinal synthesis and extracellular deposition of immuno globulin m in primary biliary cirrhosis an immuno fluorescence study of liver and small intestinal biopsy specimens. Scandinavian Journal of Gastroenterology 19(1): 97-104

Direct immunofluorescence showed intense extracellular granular deposition of IgM and [complement] C3 in liver and small-intestinal biopsy specimens from patients with primary biliary cirhosis. IgM deposits were not observed in liver tissue from patients with other liver diseases; small intestinal IgM deposits were seen in 2 of 17 patients with various intestinal disorders. The tissue deposition of IgM did not vary with plasma IgM levels, degree of cholestasis or histological stage of the disease, but seemed to reflect an abnormal property of the IgM molecule. The number of IgM-positive mononuclear cells in intestinal mucosa from patients with primary biliary cirrhosis was markedly increased, suggesting increased local synthesis of IgM. Deposition of IgM with complement-activating ability might contribute to the development of tissue damage in primary biliary cirrhosis. In addition, the apparent specificity of these IgM deposits in liver for primary biliary cirrhosis might be of diagnostic value when histological classification is difficult.


Accession: 005411511

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Related references

Lindgren, S.; McKay, J.; Hansson, I.; Eriksson, S., 1984: Evidence of increased intestinal synthesis and extracellular deposition of IgM in primary biliary cirrhosis. An immunofluorescence study of liver and small-intestinal biopsy specimens. Direct immunofluorescence showed intense extracellular granular deposition of IgM and C3 in liver and small-intestinal biopsy specimens from patients with primary biliary cirrhosis. In contrast, IgM deposits were not observed in liver tissue from...

Drumtscheva M.A.; Todoroff D.M.; Stoinoff S.G., 1983: Immuno fluorescent morphometric studies of immuno globulin forming cells in small intestinal biopsy specimens. A simplified immunofluorescent morphometric technique for the quantitative determination of Ig-forming cells (Ig-FC) in small intestinal mucosa is described. The following average values were established in 19 cases with chronic enteritis: total a...

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Vaerman J P., 1984: An increased percentage of monomeric immuno globulin a and immuno globulin a subclass 1 is present in the immuno globulin a spontaneously secreted by isolated intestinal mononuclear cells from inflammatory bowel disease patients. Gastroenterologypart 2: 1169

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