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Evidence of increased intestinal synthesis and extracellular deposition of immuno globulin m in primary biliary cirrhosis an immuno fluorescence study of liver and small intestinal biopsy specimens

, : Evidence of increased intestinal synthesis and extracellular deposition of immuno globulin m in primary biliary cirrhosis an immuno fluorescence study of liver and small intestinal biopsy specimens. Scandinavian Journal of Gastroenterology 19(1): 97-104

Direct immunofluorescence showed intense extracellular granular deposition of IgM and [complement] C3 in liver and small-intestinal biopsy specimens from patients with primary biliary cirhosis. IgM deposits were not observed in liver tissue from patients with other liver diseases; small intestinal IgM deposits were seen in 2 of 17 patients with various intestinal disorders. The tissue deposition of IgM did not vary with plasma IgM levels, degree of cholestasis or histological stage of the disease, but seemed to reflect an abnormal property of the IgM molecule. The number of IgM-positive mononuclear cells in intestinal mucosa from patients with primary biliary cirrhosis was markedly increased, suggesting increased local synthesis of IgM. Deposition of IgM with complement-activating ability might contribute to the development of tissue damage in primary biliary cirrhosis. In addition, the apparent specificity of these IgM deposits in liver for primary biliary cirrhosis might be of diagnostic value when histological classification is difficult.

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