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Evidence of inhibition and induction of microsomal enzymes in tetrahymena

, : Evidence of inhibition and induction of microsomal enzymes in tetrahymena. Experientia (Basel) 42(11-12): 1266

Microsomal cytochrome b560ms of the unicellular organism Tetrahymena was studied after triamcinolone treatment. One day of treatment decreased the enzyme concentration (nmol/mg protein); however, exposure for 2 or 3 days enhanced it. Three days of exposure increased the total protein content without further increase of microsomal enzyme concentration. The experiments demonstrate the possibility of microsomal enzyme inhibition and induction in Tetrahymena.

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Rubin, E.; Lieber, C.S., 1968: Hepatic microsomal enzymes in man and rat: induction and inhibition by ethanol. Six rats were given a diet deficient in protein and choline and 6 pair-fed rats were given the same diet in which ethanol, comprising 36% of total energy, was isocalorically substituted for carbohydrate. After 14 days rats given ethanol had increa...

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