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Evidence of insulinotropic effect from rat parotid glands


, : Evidence of insulinotropic effect from rat parotid glands. Diabetes 37(4): 441-445

Previous observations have suggested that the salivary glands exercise a regulatory role on insulin secretion and/or glucose metabolism. We have challenged the issue by studying in unanesthetized, unrestrained rats the short- and long-term effect of selective sialoadenectomy on the animals' ability to meet an intra-arterial glucose challenge. Ten-minute intra-arterial glucose tolerance tests were carried out in chronically catheterized adult rats before and after sialoadenectomy. Eighty-five to 100 days postsurgery, the parotidectomized rats experienced a 45% reduction in plasma immunoreactive insulin input (P < .001) compared with the sham-operated animals; the plasma glucose levels of the test subjects remained 19% higher (P < .001) than those of the control group. In younger rats, similar observations were made; however, the difference in insulin and glucose responses between treatments was less than in the adult rats. Our findings suggest that the insulinotropic effect resides primarily with the parotids, and the role of the submandibular glands seems to be permissive at best. We hypothesize that parotidectomy deprives the .beta.-cells of a humoral principle that appears to be essential for optimizing the immediate insulin response to a glucose challenge. These results suggest that the insulinotropic effect of the parotids is of particular importance when aging changes insulin secretion and action.

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Accession: 005411525

PMID: 3288532

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Related references

Leonora, J.; Tieche, J.M.; Cook, D.S., 1988: Evidence for insulinotropic effect from rat parotid glands. Previous observations have suggested that the salivary glands exercise a regulatory role on insulin secretion and/or glucose metabolism. We have challenged the issue by studying in unanesthetized, unrestrained rats the short- and long-term effect...

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Chilla, R.; Hoffmann, G.; Arglebe, C., 1977: The "stimulatory proteodyschylia" in the amitriptylin (Laroxyl) treated rat parotid gland. Experiments on the effect of antidepressive pharmacotherapy on the parotid glands of the rat. The activity of total amylase and isoamylases in the rat parotid gland is reduced by treatment with Amitriptylin (Laroxyl) for 3 and 7 days while the protein content of the glands remains constant. These changes are no longer visible after treatme...

Mizuta, H., 1975: Enlargement of the parotid glands in rats on low protein diet. 1. Changes in the weight of the parotid glands. Igaku Kenkyu. Acta Medica 45(4): 205-211

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Goldenberg, D.; Flax-Goldenberg, R.; Joachims, H.Z.; Peled, N., 2001: Misplaced parotid glands: bilateral agenesis of parotid glands associated with bilateral accessory parotid tissue. Agenesis of the parotid is a rare entity. It is usually unilateral but bilateral cases have been described as a rare cause of xerostomia. Accessory parotid tissue is also uncommon and is not normally associated with aplasia of the parotid gland. T...

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