EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence of insulinotropic effect from rat parotid glands






Diabetes 37(4): 441-445

Evidence of insulinotropic effect from rat parotid glands

Previous observations have suggested that the salivary glands exercise a regulatory role on insulin secretion and/or glucose metabolism. We have challenged the issue by studying in unanesthetized, unrestrained rats the short- and long-term effect of selective sialoadenectomy on the animals' ability to meet an intra-arterial glucose challenge. Ten-minute intra-arterial glucose tolerance tests were carried out in chronically catheterized adult rats before and after sialoadenectomy. Eighty-five to 100 days postsurgery, the parotidectomized rats experienced a 45% reduction in plasma immunoreactive insulin input (P < .001) compared with the sham-operated animals; the plasma glucose levels of the test subjects remained 19% higher (P < .001) than those of the control group. In younger rats, similar observations were made; however, the difference in insulin and glucose responses between treatments was less than in the adult rats. Our findings suggest that the insulinotropic effect resides primarily with the parotids, and the role of the submandibular glands seems to be permissive at best. We hypothesize that parotidectomy deprives the .beta.-cells of a humoral principle that appears to be essential for optimizing the immediate insulin response to a glucose challenge. These results suggest that the insulinotropic effect of the parotids is of particular importance when aging changes insulin secretion and action.

(PDF 0-2 workdays service: $29.90)

Accession: 005411525

PMID: 3288532



Related references

Effect of single dose irradiation to parotid gland on the structured and function changes of bilateral parotid glands in miniature pig. Hua Xi Kou Qiang Yi Xue Za Zhi 24(1): 83-5, 88, 2006

Enlargement of the parotid glands in rats on low protein diet. 1. Changes in the weight of the parotid glands. Igaku Kenkyu. Acta Medica 45(4): 205-211, 1975

The stimulatory proteodyschylia in the amitriptyline laroxyl treated rat parotid gland experiments on the effect of anti depressive pharmaco therapy on the parotid glands of the rat. Archives of Oto Rhino Laryngology 217(1): 61-68, 1977

Misplaced parotid glands: bilateral agenesis of parotid glands associated with bilateral accessory parotid tissue. Journal of Laryngology and Otology 114(11): 883-885, 2001

Keratoconjunctivitis sicca and buccoglossopharyngitis sicca with enlargement of parotid glands; report of two cases of Sjögren's syndrome, with pathologic study of a lacrimal gland and the parotid glands in one case. Archives of Ophthalmology 35: 227-240, 2012

Keratoconjunctivitis sicca and Bucco-glossopharynigitis sicca with enlargement of the parotid glands A report of two cases The pathology of a lacrimal and the parotid glands of a case. 1946

Relationships between salivary glands and endocrine glands. II. Effect of exogenous testosterone on the deoxycytidylate-amino-hydrolase content of the parotid gland of the albino rat. Archivio Stomatologico 9(3): 283-289, 1968

Restoration of the insulinotropic effect of glucose-dependent insulinotropic polypeptide contributes to the antidiabetic effect of dipeptidyl peptidase-4 inhibitors. Diabetes, Obesity & Metabolism 17(1): 74-81, 2015

Further evidence for AQP8 expression in the myoepithelium of rat submandibular and parotid glands. Pflugers Archiv 451(5): 642-645, 2005

Sebaceous glands in normal and neoplastic parotid glands; possible significance of sebaceous glands in respect to the origin of tumors of the salivary glands. American Journal of Pathology 25(4): 627-645, 1949