EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence of lung surfactant abnormality in respiratory failure broncho alveolar lavage phospho lipids surface activity phospho lipase activity and plasma myo inositol


, : Evidence of lung surfactant abnormality in respiratory failure broncho alveolar lavage phospho lipids surface activity phospho lipase activity and plasma myo inositol. Journal of Clinical Investigation 70(3): 673-683

Lung surfactant is damaged in the adult respiratory distress syndrome. Bronchoalveolar lavage specimens (225: 78 from 36 patients 1-78 yr old with respiratory failure, 135 from another 128 patients with other respiratory disease and 12 from healthy controls) were assayed for the lung profile [lecithin/sphingomyelin (L/S) ratio, saturated lecithin, phosphatidylinositol and phosphatidylglycerol]. Bronchoalveolar lavage fluid was analyzed for phospholipids and for phosphatidic acid phosphohydrolase, phospholipase A2 and phosphatidylinositol phosphodiesterase activities. A lipid-protein complex was isolated and analyzed for surface activity and plasma was measured for myoinositol. There were only small differences seen in the recovery of total phospholipid between respiratory failure patients and normal controls. In respiratory failure, phospholipids in bronchoalveolar lavage were qualitatively different from those recovered either from normal controls or from patients with other lung disease: the L/S ratio, phosphatidylglycerol and disaturated lecithin were low, whereas sphingomyelin and phosphatidylserine were prominent. These abnormalities were present early in respiratory failure and tended to normalize during recovery. Low L/S ratio (< 2) and low phosphatidylglycerol (1% or less of glycerophospholipids) in bronchoalveolar lavage was always associated with respiratory failure. Abnormal lavage phospholipids were not due to plasma contamination. The phospholipase studies revealed little evidence of increased catabolism of phospholipids. In respiratory failure, the lipid-protein complexes from lung lavage were not surface active, whereas that from healthy controls had surface properties similar to lung surfactant. Phospholipids from patients with respiratory failure were similar to those from respiratory distress syndrome in the newborn. The latter condition was characterized by fast recovery of surfactant deficiency and by high plasma myoinositol that suppressed the synthesis of surfactant phosphatidylglycerol and increased phosphatidylinositol. In adult respiratory distress syndrome, the abnormality in surfactant phospholipids may last for weeks and in most cases is associated with low phosphatidylinositol, low phosphatidylglycerol and low plasma myoinositol.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005411556

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Nugent, T. J., 1956: Soil treatments with PCNB (terraclor) for control of Potato scab. Field trials were carried out in 1955 at the Virginia Truck Experiment Substation, Onley, to test the effectiveness of PCNB (pentachloronitrobenzene) against potato scab (Streptomyces scabies) under eastern Virginia conditions. The dust was applie...

Kirova T. V., 1956: O chetvertichnykh tektonicheskikh razryvakh v Rudnom Altae. Faulting in Quaternary time in the Rudnyi Altai region, USSR, followed lines of Paleozoic dislocation.

Yetkin, E.; Waltenberger, J., 2007: Novel insights into an old controversy. Coronary artery ectasia (CAE) is defined as a localized or diffuse non-obstructive lesion of the epicardial coronary arteries with a luminal dilation exceeding 1.5-fold the diameter of the normal adjacent arterial segment. The incidence of CAE ha...

Weller, Christine Buchanan; Reeder, Christopher, 2001: Traumatic pseudoaneurysm of the superficial temporal artery: Two cases. Pseudoaneurysms of the superficial temporal artery are a rare and potentially critical cause of facial masses. Most pseudoaneurysms form as a result of blunt trauma and present as painless, pulsatile tumors that may be associated with neuropathic...

Lutfalla, Georges; Gardiner, Katheleen; Uze, Gilles, 1993: A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. A full-length cDNA corresponding to a gene mapping to the D21S58 locus was cloned. The encoded protein, called CRF2-4, was shown to be a typical class II member of the cytokine receptor family. The gene encoding CRF2-4 spans more than 30 kb. Its i...

Babak, Edward, 1913: Zur Regulation des Atemstromes bei den Lamellibranchiaten. Zugleich ein Beitrag zur Physiologie der Flimmerbewegung. Zs Physiol. Jena: 184-198

Verschuuren, E. A.; Popa, E. R.; Van Der Bij, W.; Harmsen, M. C.; The, T. H.; Hepkema, B., 2001: Donor or recipient origin of post transplant lymphoproliferative disease after lung transplantation. Journal of Heart & Lung Transplantation 20(2): 199, February

Larochelle, Andre; Lariviere, Marie Claude, 2002: A natural history of the ground-beetles of America north of Mexico. This 583-page book, part of a series on faunal reviews is a summary of the natural history of the over 2,400 species of ground beetles (Coleoptera, Carabidae) from North America north of Mexico. Species accounts include information on ecology, bio...

De Jonge, Christopher J.; Flaherty, Sean P.; Barnes, Annette M.; Swann, Nicholas J.; Matthews, Colin D., 1997: Failure of multitube sperm swim-up for sex preselection. Objective: To use double-label fluorescence in situ hybridization to evaluate a modified swimup procedure that is purported to be effective for preconceptual sex selection. Design: Controlled, blinded study. Setting. University hospital laboratori...

Matsumoto, Yoshihiro; Suzuki, Yumiko; Ishii, Yukiko; Ishihara, Rika; Nakazawa, Arisa; Nakane, Yutaka; Nishinari, Chisato; Deguchi, Koichi, 1998: Antimicrobial activity of ofloxacin against recent clinical isolates from otitis media and otitis externa. In order to evaluate the annual changes of susceptibility, minimum inhibitory concentrations (MICs) of ofloxacin (OFLX) and 4 control drugs were determined against clinical isolates that were obtained from patients with otitis media and otitis ext...