+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Evidence of morphine in urine samples

Zeitschrift fuer Rechtsmedizin 95(2): 85-96
Evidence of morphine in urine samples
In TLC screenings of 335 urine samples taken because of suspicion of heroin consumption, positive evidence of morphine was found in about 50% of the cases, which was confirmed without exception by gas chromatography-mass spectrometry. In 66% of the positive cases, morphine and codeine were found; in about 31% only morphine was found, and the median value of 0.4 mg/l free morphine and 1.0 mg/l conjugated morphine was considerably lower than in the whole collection of samples. Comparison of the codeine/morphine quotients (Q), especially the free bases, proves that the groups of heroine/morphine or codeine consumers can be distinctly differentiated. The critical conditions of the conjugated bases worked out by Dutt et al. (1983) proved to be right. Using the equation Qf < 0.5 .sqroot.c, a boundary condition for the free flare bases can also be developed, which is dependent on the sum of the codeine and morphine concentrations and which proves heroin/morphine consumption with 98% certainty.

(PDF 0-2 workdays service: $29.90)

Accession: 005411576

Related references

Interpretation of the presence of 6-monoacetylmorphine in the absence of morphine-3-glucuronide in urine samples: evidence of heroin abuse. Therapeutic Drug Monitoring 25(5): 645-648, 2003

Detection of morphine in blood and urine samples from horses administered poppy seeds and morphine sulfate orally. Journal of Analytical Toxicology 26(2): 81-86, 2002

Simultaneous determination of morphine, codeine and 6-acetyl morphine in human urine and blood samples using direct aqueous derivatisation: validation and application to real cases. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences 949-950: 127-132, 2014

Identification of morphine and codeine in urine samples by use of derived spectrophotometry. Travaux Scientifiques des Chercheurs du Service de Sante des Armees (8): 231-232, 1987

In vitro conversion of morphine to 6-acetylmorphine in urine samples during enzymatic hydrolysis. Clinical Chemistry 60(9): 1234-1235, 2014

Extraction of benzoylecgonine (cocaine metabolite) and opiates (codeine and morphine) from urine samples using the Zymark RapidTrace. Journal of Analytical Toxicology 20(7): 587-591, 1996

Morphine to codeine concentration ratio in blood and urine as a marker of illicit heroin use in forensic autopsy samples. Forensic Science International 217(1-3): 216-221, 2012

Strip-based immunochromatographic assay using specific egg yolk antibodies for rapid detection of morphine in urine samples. Biosensors & Bioelectronics 25(2): 502-505, 2009

Influence of phenobarbital on morphine metabolism and disposition: LC-MS/MS determination of morphine (M) and morphine-3-glucuronide (M3G) in Wistar-Kyoto rat serum, bile, and urine. Current Drug Metabolism 8(1): 79-89, 2007

Serum and urine concentrations of morphine and morphine metabolites in patients with advanced cancer receiving continuous intravenous morphine: an observational study. Bmc Palliative Care 14(): 53-53, 2016