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Evidence of oxygen limitation in a hollow fiber reactor with immobilized escherichia coli


, : Evidence of oxygen limitation in a hollow fiber reactor with immobilized escherichia coli. Biotechnology Letters 8(8): 561-564

A hollow fibre reactor (HFR) has been used to immobilize a regulatory mutant of E. coli to produce phenylalanine. Fermentation performance in the HFR using both air and pure oxygen shows evidence of significant oxygen limitation. In particular, levels of volatile fatty acids (VFA) produced served as an indication of oxygen limitation.

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