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Evidence of place conditioning after chronic intrathecal morphine in rats


Pharmacology Biochemistry & Behavior 22(2): 271-278
Evidence of place conditioning after chronic intrathecal morphine in rats
The acute administration of systemic or intrathecal morphine produced an antinociceptive reaction on the tail flick test; only systemic morphine produced a sedative effect on motor activity. Rats receiving chronic intrathecal injections were hyperactive relative to saline injected control subjects. After a series of 4 injections, a place preference was induced by both routes of administration; rats who had previously received morphine either by s.c. or intrathecal injection spent significantly more time in the context in which the drug had been given, relative to rats who were comparably injected with saline. Apparently, chronic intrathecal morphine in rats may elicit a discriminable cue, either through direct pharmacological stimulation of supraspinal sites, or, indirectly, as a consequence of spinal opiate action.

Accession: 005411652

PMID: 3838587

DOI: 10.1016/0091-3057(85)90390-9

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