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Evidence of red blood cell membrane lipid per oxidation in hemo dialysis patients

, : Evidence of red blood cell membrane lipid per oxidation in hemo dialysis patients. Nephron 36(4): 235-237

Some metabolic alterations of the pentose-phosphate shunt can increase susceptibility to red blood cell (RBC) lipid peroxidation in uremic patients on maintenance hemodialysis. This phenomenon was investigated in 19 uremic patients undergoing chronic hemodialysis by determining RBC malonyldialdehyde (MDA), a secondary product of lipid peroxidation and plasma and RBC tocopherols, which are powerful antioxidants. Evidence of RBC membrane lipid peroxidation was demonstrated by an increase of RBC MDA. RBC tocopherols were significantly decreased because of enhanced antioxidant activity. No significant variations of these parameters were found before and after dialysis.

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