EurekaMag.com logo
+ Translate

Evidence of reversibility of age related decrease in human lymphocyte adenylate cyclase activity


, : Evidence of reversibility of age related decrease in human lymphocyte adenylate cyclase activity. Biochemical & Biophysical Research Communications 99(3): 1028-1034

Age-related loss of adenylate cyclase responsiveness to guanyl nucleotide was demonstrated in lymphocytes freshly isolated from human subjects. Enzyme activity of cells from young (< 40 yr) and elderly (> 65 yr) subjects were markedly sensitive to inhibition by non-ionic detergents. When enzyme activity in the presence of guanyl nucleotide and low concentrations of Triton X-100 was determined in a mixture of cells from the young and aged donors, the activity was 40 .+-. 17% (mean .+-. SD) greater than anticipated from the activity of the cells of the 2 age groups assayed separately. The detergent range which facilitated the enhanced enzyme activity was too low to extract the catalytic subunit of adenylate cyclase from the cells. Changes distal to receptors apparently contribute to diminished responsiveness of lymphocyte adenylate cyclase as a function of age. These age-related changes may be partially reversible by reconstitution with factors from cells from younger subjects.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005411700

PMID: 7247941

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Croxatto J.O.; Rao N.A.; Mclean I.W.; Marak G.E., 1982: Atypical histo pathologic features in sympathetic ophthalmia a study of 100 cases. Cases (100) of clinically acceptable [human] sympathetic ophthalmia (SO) were evaluated histologically to determine the incidence of atypical features and to correlate them with the severity of choroidal inflammation. The inflammatory response in...

Welch, Cm, 1984: Mild-cure formaldehyde-free durable-press finishing of cotton textiles with glyoxal and glycols. United States patent United States Patent Office: 8, 1984 (4,472,167)

Strijkers, K.; Costa, A., 2011: Riding the lexical speedway: a critical review on the time course of lexical selection in speech production. Speech requires time. How much time often depends on the amount of labor the brain has to perform in order to retrieve the linguistic information related to the ideas we want to express. Although most psycholinguistic research in the field of lang...

Krotevich N.F.; Sergeyev V.G., 1983: Portable highly-sensitive magnetic susceptibility measuring instrument. Geofizicheskaya Apparatura 78(1983

Cochrane C.G., 1972: An allergic triggering mechanism of immune complex deposition in rabbits. Arthritis & Rheumatism: 103-104

Hunter, C.; Christian, D., 2014: Parasite uses host NFAT to co-opt immune response. Journal of Experimental Medicine 211(10): 1923-1923

Patenaude, A.; Woerher, S.; Umlandt, P.; Wong, F.; Ibrahim, R.; Kyle, A.; Unger, S.; Fuller, M.; Parker, J.; Minchinton, A.; Eaves, C.J.; Karsan, A., 2016: A novel population of local pericyte precursor cells in tumor stroma that require Notch signaling for differentiation. Pericytes are perivascular support cells, the origin of which in tumor tissue is not clear. Recently, we identified a Tie1(+) precursor cell that differentiates into vascular smooth muscle, in a Notch-dependent manner. To understand the involvemen...

Heim, I.; Nickel, M., 2010: Description and molecular phylogeny of Tethya leysae sp nov Porifera, Demospongiae, Hadromerida from the Canadian Northeast Pacific with remarks on the use of microtomography in sponge; taxonomy. The sponge Tethya leysae sp. nov. (Porifera, Demospongiae, Hadromerida, Tethyidae) is a new species from the Canadian Northeast Pacific. Its type locality is the infralittoral around Ohiat Islet, Barkely Sound, Vancouver Island in Canada. Tethya l...

Chen, L.; Gao, C.; Zhu, Y.; Zhong, W.; Hu, Y.; Zhang, X., 2011: Two novel monoclonal antibodies produced against human CD83 molecule. CD83, a maturation marker for human and mouse dendritic cells (DCs), plays a critical role in CD4(+) T cell development as well as peripheral immune regulation. Here, two novel mouse anti-human CD83 monoclonal antibodies (MAbs) were prepared and t...

Rice, S.A.; McDougald, D.; Kumar, N.; Kjelleberg, S., 2005: The use of quorum-sensing blockers as therapeutic agents for the control of biofilm-associated infections. The development of novel antimicrobial compounds is required to treat the growing number of infections where antibiotic resistance is a serious threat, especially in situations where biofilms are involved. Antibiotic resistance is the result of tw...