EurekaMag.com logo
+ Translate

Evidence of serotonin dopamine involvement in the inhibition of dextro amphetamine stereotypy and appearance of stereotyped movements found respectively after acute and long term treatment with morphine and methadone in rats


, : Evidence of serotonin dopamine involvement in the inhibition of dextro amphetamine stereotypy and appearance of stereotyped movements found respectively after acute and long term treatment with morphine and methadone in rats. Life Sciences 29(25): 2585-2592

p-Chlorophenylalanine, an inhibitor of serotonin synthesis, completely prevented the inhibitory effect of morphine and methadone on the stereotypy caused by d-amphetamine and methylphenidate in rats. d-Fenfluramine and m-chlorophenylpiperazine, 2 drugs supposed to increase serotonin transmission, and haloperidol, an antagonist of dopamine at central receptors, blocked the stereotyped movements induced by repeated treatment with morphine and methadone. Apparently, brain serotonin mediates the effect of morphine and methadone on amphetamine and methylphenidate stereotypy, and serotonin and dopamine are involved in the stereotyped movements caused by long-term treatment with these narcotics in the rat.

(PDF 0-2 workdays service)

Accession: 005411720

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Cervo, L.; Romandini, S.; Samanin, R., 1981: Evidence of serotonin-dopamine involvement in the inhibition of d-amphetamine stereotypy and appearance of stereotyped movements found respectively after acute and long-term treatment with morphine and methadone in rats. Life Sciences 29(25): 2585-2591

Cox B.; Tha S.J., 1973: Effects of amantadine and l dopa on apo morphine and dextro amphetamine induced stereotyped behavior in rats. European Journal of Pharmacology 24(1): 96-100

Segal D.S.; Mandell A.J., 1974: Long term administration of dextro amphetamine progressive augmentation of motor activity and stereotypy. Pharmacology Biochemistry & Behavior 2(2): 249-255

Jackson D.M.; Bailey R.C.; Christie M.J.; Crisp E.A.; Skerritt J.H., 1981: Long term dextro amphetamine in rats lack of change in postsynaptic dopamine receptor sensitivity. Treatment of rats with d-amphetamine (5 mg/kg) once daily for 25 days did not change locomotor responses, on day 7 of withdrawal, to dopamine (DA) or d-amphetamine into the nucleus accumbens. Nor was there a change in 3H-spiperone binding of cauda...

Klawans H.L.; Margolin D.I.; Dana N.; Crosset P., 1975: Super sensitivity to dextro amphetamine induced and apo morphine induced stereotyped behavior induced by chronic dextro amphetamine administration. Journal of the Neurological Sciences 25(3): 283-290

Neuburg J.; Thut P.D., 1974: Comparison of the loco motor stimulant mechanisms of action of dextro amphetamine and dextro amphetamine plus l dopa possible involvement of serotonin. Biological Psychiatry 8(2): 139-150

Spampinato, U.; Nowakowska, E.; Samanin, R., 1983: Increased release of striatal dopamine after long-term treatment with methadone in rats: inhibition by agents which increase central 5-hydroxytryptamine transmission. Journal of Pharmacy and Pharmacology 35(12): 831-833

Heinze W.J.; Schlemmer R.F.Jr; Javaid J.I.; Davis J.M., 1981: The comparative effects of dextro lsd and dextro amphetamine on stereotyped behavior in rats. Federation Proceedings 40(3 PART 1): 277

Finnegan K.T.; Ricaurte G.; Seiden L.S.; Schuster C.R., 1982: Altered sensitivity to dextro methyl amphetamine apo morphine and haloperidol in rhesus monkeys depleted of caudate dopamine by repeated administration of dextro methyl amphetamine. The long-term neurochemical and behavioral effects of repeated d-methylamphetamine (d-MA) administration were investigated using 4 male rhesus monkeys trained to lever-press for food on a DRL[differential low rate of reinforcement]-40 s schedule o...

Rosecrans J.A.; Chance W.T.; Schechter M.D., 1976: The discriminative stimulus properties of nicotine dextro amphetamine and morphine in dopamine depleted rats. Psychopharmacology Communications 2(4): 349-356