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Evidence of serotonin dopamine involvement in the inhibition of dextro amphetamine stereotypy and appearance of stereotyped movements found respectively after acute and long term treatment with morphine and methadone in rats

, : Evidence of serotonin dopamine involvement in the inhibition of dextro amphetamine stereotypy and appearance of stereotyped movements found respectively after acute and long term treatment with morphine and methadone in rats. Life Sciences 29(25): 2585-2592

p-Chlorophenylalanine, an inhibitor of serotonin synthesis, completely prevented the inhibitory effect of morphine and methadone on the stereotypy caused by d-amphetamine and methylphenidate in rats. d-Fenfluramine and m-chlorophenylpiperazine, 2 drugs supposed to increase serotonin transmission, and haloperidol, an antagonist of dopamine at central receptors, blocked the stereotyped movements induced by repeated treatment with morphine and methadone. Apparently, brain serotonin mediates the effect of morphine and methadone on amphetamine and methylphenidate stereotypy, and serotonin and dopamine are involved in the stereotyped movements caused by long-term treatment with these narcotics in the rat.

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